Transmission and clinical characteristics of coronavirus disease 2019 in 104 outside-Wuhan patients, China

Abstract

BackgroundCases with coronavirus disease 2019 (COVID-19) emigrated from Wuhan escalated the risk of spreading in other cities. This report focused on the outside-Wuhan patients to assess the transmission and clinical characteristics of this illness. MethodsContact investigation was conducted on each patient who admitted to the assigned hospitals in Hunan Province (geographically adjacent to Wuhan) from Jan 22, 2020 to Feb 12, 2020.Demographic, clinical, laboratory and radiological characteristics, medication therapy and outcomes were collected and analyzed. Patients were confirmed by PCR test. ResultsOf the 104 patients, 48 (46.15%) were imported cases and 56 (53.85%) were indigenous cases; 93 (89.42%) had a definite contact history with infections. Family clusters were the major body of patients. Transmission along the chain of 3 "generations" was observed. Mean age was 43 (rang, 8-84) years (including 3 children) and 49 (47.12%) were male. Most patients had typical symptoms, 5 asymptomatic infections were found and 2 of them infected their relatives. The median incubation period was 6 (rang, 1-32) days, of 8 patients ranged from 18 to 32 days. Just 9 of 16 severe patients required ICU care. Until Feb 12, 2020, 40 (38.46%) discharged and 1 (0.96%) died. For the antiviral treatment, 80 (76.92%) patients received traditional Chinese medicine therapy. All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

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Presymptomatic Transmission and Diverse Progression of Familial Clustering Covid-19 Cases in Zhoushan, China

“…The case number keepsincreasing. As of June 9, 2020, the global con rmed COVID-19 cases and deaths increased to 7039918 and 404396, respectively [2].Family clustering and hospital-based transmission were the two major epidemiological features of this outbreak at the early stage, and continued to be an important cause of community-based SARS-CoV-2 transmission in a low prevalence region [3][4][5][6][7][8].However, data concerning SARS-CoV-2 transmissibility in the incubation period and the diversity in disease progression among affected family members are very limited.…”

Presymptomatic transmission and diverse progression of familial clustering COVID-19 cases in Zhoushan, China

“…As of June 9, 2020, the global con rmed COVID-19 cases and deaths increased to 7039918 and 404396, respectively [2]. Family clustering and hospital-based transmission were the two major epidemiological features of this outbreak at the early stage, and continued to be an important cause of community-based SARS-CoV-2 transmission in a low prevalence region [3][4][5][6][7][8]. However, data concerning SARS-CoV-2 transmissibility in the incubation period and the diversity in disease progression among affected family members are very limited.…”