Transmission and age-at-onset patterns in familial Alzheimer??s disease: evidence for heterogeneity

Heredity in dementia of the Alzheimer type

“…Family studies have suggested that early onset of Alzheimer's disease is genetically determined, since first-degree relatives of probands with DAT exhibit a significantly increased risk (Sjragren et al 1952, Larsson & Jacobsen 1963, Akesson 1969, Heyman et al 1983, Heston et al 1981, Heston & White 1990, Breitner et al 1988, Mohs et al 1987, Martin et a]. 1988, Farrer et al 1990).…”