Transmissible Venereal Tumor with Subcutaneous and Bone Metastasis in a Dog

Abuom, T.O; Mande, John D.

doi:10.4314/kenvet.v30i1.39617

Cited by 2 publications

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“…Metastasis of TVT from primary genital sites is uncommon but is usually seen in the regional lymphnodes [4]. Other reported sites of metastasis include skin, subcutaneous, distant lymphnodes, brain, eyes, spleen, liver, testicles, musculature, lungs, kidneys, anus, bones, mammary glands [6,8,[11][12][13][14]. In the current study, TVT was detected in most of the sites reported above apart from metastasis to the rectum, anus, kidneys and the brain.…”

Section: Discussionsupporting

confidence: 49%

Genital and Extragenital Canine Transmissible Venereal Tumor in Dogs in Grenada, West Indies

Chikweto

Kumthekar²,

Larkin³

et al. 2013

OJVM

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Transmissible venereal tumor (TVT) is a widely reported transplantable tumor in dogs, with no breed or sex predilection and with a low metastatic rate. This retrospective study conducted from 2005 and 2011 sought to evaluate the total number of TVT cases, and to report extragenital TVT lesions in dogs from the small tropical island of Grenada, West Indies. Evaluation of the biopsy and necropsy specimens from dogs with TVT was carried out by cytological and histopathological methods. In the present study, we observed a total of 78 dogs with TVT, comprising 40 male and 38 female dogs. Most cases were from dogs between 3 and 6 years; less frequently from older dogs (over 6 years) or younger dogs (1-2 years of age). In the present study, we report 15 cases (19.2%) of dogs with TVT in extragenital sites. Tumors were noted in the nasal cavity, eye orbit, spleen, liver, skin, ribs, subcutaneous, and submandibular, cervical and inguinal lymph nodes. There was also evidence of metastasis to the ovaries in 2 dogs. The most interesting finding was the presence of extragenital lesions without primary genital involvement in 4 cases (5.1%). Our findings emphasize the need to consider TVT on the list of differential diagnosis for masses in extragenital sites in dogs from geographic regions where TVT is prevalent.

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Section: Discussionsupporting

confidence: 49%

Genital and Extragenital Canine Transmissible Venereal Tumor in Dogs in Grenada, West Indies

Chikweto

Kumthekar²,

Larkin³

et al. 2013

OJVM

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“…In connection with this, difficulties arise in the early diagnosis, treatment and prevention of this disease. Canine transmissible venereal sarcoma usually occurs more often than it is diagnosed, since objective clinical manifestations (bleeding, ulcers, changes in the anatomical structure of the genital organs) are detected only at the stage when the tumor affects the main part of the genital organs [7,8].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Methods of Canine Transmissible Venereal Sarcoma

Pashkevych

Stybel

Soroka

2018

EUREKA: Health Sciences

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Modern diagnostic of oncological diseases, along with classical clinical and morphological methods, provides for the mandatory use of instrumental immunological, immunocytochemical and molecular genetic research methods. The main tasks of such a complex of diagnostic measures are aimed at monitoring oncological diseases at all stages of the diagnostic and treatment process, namely: the detection of a tumor at early stages of its development and the study of changes in metabolic processes in the body under the influence of neoplasms, morphological confirmation of the diagnosis, identification of histostructure and histogenesis of the tumor, determination the degree of its malignancy, detection of metastatic lesion (regional and distant lymph nodes and other organs) or assessment of the risk of its occurrence. It is well know that the early stages of oncological diseases are difficult to diagnose. At the same time, early detection of the disease can save or significantly extend the life of the patient. In such cases, the determination in the blood of specific substances, which are produced by tumors of the respective organs, the so-called oncomarkers, has been successfully used by world medical practice for more than 40 years to establish the affected organ. In combination with instrumental methods (ultrasound, endoscopy, X-ray), diagnostic efficiency is sharply increasing. Successful treatment of malignant tumors is possible under the conditions of their early detection and thorough histological diagnosis. Almost 50 % of the total number of oncologically diseased dogs has tumorous processes in the tissues of their genital organs, aggressiveness and metastasis, which often leads to lethal consequences, even after radical interventions. The aim of our research was to study the histological, cytological and immunohistochemical characteristics of transmissible venereal sarcoma. It has be en established that histologically, the tumor belongs to the low-differentiated round-cellular sarcoma of the alveolar type. Typical is tumor infiltration by lymphocytes, plasma cells, macrophages. Tumor cells are characterized by the presence of a mesenchymal marker vimentine. A positive local reaction on myogenin, cytokeratin and negative on CD31, CD34, S-100 protein and desmin was observed.

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Transmissible Venereal Tumor with Subcutaneous and Bone Metastasis in a Dog

Cited by 2 publications

References 0 publications

Genital and Extragenital Canine Transmissible Venereal Tumor in Dogs in Grenada, West Indies

Genital and Extragenital Canine Transmissible Venereal Tumor in Dogs in Grenada, West Indies

Diagnostic Methods of Canine Transmissible Venereal Sarcoma

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