Transmissão oral da doença de Chagas pelo consumo de açaí: um desafio para a Vigilância Sanitária

Ferreira, Renata Trotta Barroso; Branquinho, Maria Regina; Leite, Paola Cardarelli

doi:10.3395/vd.v2i4.358

Cited by 8 publications

(5 citation statements)

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“…Several studies show that most outbreaks of acute Chagas disease are associated with açaí [36][37][38][39] , which is the main food responsible for the increase in the number of cases of Chagas disease in the North region in recent years, whether due to fruit or pulp contamination by means of waste from the infected triatomines in the endemic areas 40 , which have already been registered in the state with the occurrence of the following species: Rhodnius robustus 29 , Rhodnius pictipes 29 , Rhodnius montenegrensis 41 , Rhodnius stali 16 , Rhodnius neglectus 42 , Eratyrus mucronatus 13 , Panstrongylus geniculatus 12 , Panstrongylus megistus 43 and Triatoma sordida 44 .…”

Section: Discussionmentioning

confidence: 99%

Retrospective study of the epidemiological overview of the transmission of Chagas disease in the State of Acre, South-Western Amazonia, from 2009 to 2016

Oliveira¹,

Ribeiro²,

Castro³

et al. 2018

J. Hum. Growth Dev.

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Introduction: Chagas disease (CD), also known as American Trypanosomiasis, is an infectious parasitic disease caused by the etiologic agent Trypanosoma cruzi. It is considered endemic in the low-income population and is classified by the WHO as a neglected tropical disease. In the state of Acre, there is almost no scientific data regarding the epidemiology of CD, even though the first autochthonous case was registered in the 1980s. Objective: To analyze the epidemiological panorama of the transmission of Chagas disease in the State of Acre, Brazil, from 2009 to 2016. Methods: A survey of the occurrence of Chagas disease in the State of Acre was performed using public domain secondary data from the Brazil’s Notifiable Diseases Information System of SUS (publicly funded health care system), and from the SUS Database of the Health Surveillance Foundation of the State of Acre. Data were collected from the following variables: gender, age group, form of contagion, distribution by region and municipality, perimeter and seasonality. Result: Forty-two cases of CD were confirmed, with an increase of more than 300% from 2015 to 2016 and a frequency coefficient of 3.06 cases per 100,000 people, and in the Tarauacá/Envira region, the probability of a person contracting CD was 600% higher than the state mean. Conclusion: We found that in the state of Acre, in the period from 2009 to 2016, most cases of CD occurred in 2016, in the Tarauacá/Envira region, mainly in the municipality of Feijó, in the rural zone, from July to October, in the age group of 0 to 30 years, being the oral form the main route of transmission and presenting no statistical difference between men and women.

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Section: Discussionmentioning

confidence: 99%

Retrospective study of the epidemiological overview of the transmission of Chagas disease in the State of Acre, South-Western Amazonia, from 2009 to 2016

Oliveira¹,

Ribeiro²,

Castro³

et al. 2018

J. Hum. Growth Dev.

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“…By contrast hosts can become infected with T. cruzi through several avenues, including congenital and oral, but the most common and important is vector-borne transmission [8]. Oral transmission through predation of infected vectors is thought to be the most frequent mechanism of infection among hosts in the sylvatic cycle [9–14] and many people have been infected orally in focalized outbreaks in Latin America [9,15]. The probability of transmission due to oral vector ingestion is about 1000 times greater than vectorial transmission [16,17] and T. cruzi parasites in feces outside of the bug are viable (infectious) for up to 48 hours [17].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, due to the scarcity of insecticide for public health usage [45], treatment of canines with a safe, long-lasting, effective insecticide such as fluralaner potentially could prove a valuable tool in the face of pyrethroid shortage [6,33]. However, given that T. cruzi can be easily transmitted orally through the ingestion of triatomines [9,13,15,46–49], there is potential for a counterproductive effect: dogs could consume the infected bugs killed by the treatment [27,35,50], increasing infection rates in the dog population.…”

Section: Introductionmentioning

confidence: 99%

Modeling the impact of xenointoxication in dogs to haltTrypanosoma cruzitransmission

Rokhsar

Raynor

Sheen

et al. 2023

Preprint

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Background: Chagas disease, a vector-borne parasitic disease caused by Trypanosoma cruzi, affects millions in the Americas. Dogs are important reservoirs of the parasite. Under laboratory conditions, canine treatment with the systemic insecticide fluralaner demonstrated efficacy in killing Triatoma infestans and T. brasiliensis, T. cruzi vectors, when they feed on dogs. This form of pest control is called xenointoxication. However, T. cruzi can also be transmitted orally when mammals ingest infected bugs, so there is potential for dogs to become infected upon consuming infected bugs killed by the treatment. Xenointoxication thereby has two contrasting effects on dogs: decreasing the number of insects feeding on the dogs but increasing opportunities for exposure to T. cruzi via oral transmission to dogs ingesting infected insects. Objective: Examine the potential for increased infection rates of T. cruzi in dogs following xenointoxication. Design/Methods: We built a deterministic mathematical model, based on the Ross-MacDonald malaria model, to investigate the net effect of fluralaner treatment on the prevalence of T. cruzi infection in dogs in different epidemiologic scenarios. We drew upon published data on the change in percentage of bugs killed that fed on treated dogs over days post treatment. Parameters were adjusted to mimic three scenarios of T. cruzi transmission: high and low disease prevalence and domestic vectors, and low disease prevalence and sylvatic vectors. Results: In regions with high endemic disease prevalence in dogs and domestic vectors, prevalence of infected dogs initially increases but subsequently declines before eventually rising back to the initial equilibrium following one fluralaner treatment. In regions of low prevalence and domestic or sylvatic vectors, however, treatment seems to be detrimental. In these regions our models suggest a potential for a rise in dog prevalence, due to oral transmission from dead infected bugs. Conclusion: Xenointoxication could be a beneficial and novel One Health intervention in regions with high prevalence of T. cruzi and domestic vectors. In regions with low prevalence and domestic or sylvatic vectors, there is potential harm. Field trials should be carefully designed to closely follow treated dogs and include early stopping rules if incidence among treated dogs exceeds that of controls.

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“…A DC trata-se de uma antropozoonose causada pelo protozoário Trypanosoma cruzi, tendo como principal vetor o triatomídeo hematófago e sua transmissão pode ocorrer ao homem via vetorial (repasto sanguíneo com excretas de triatomíneo na pele ou mucosa lesada); via transfusional, por transfusão de hemoderivados ou transplantes de órgão por doadores contaminados; via vertical ou congênita entre gestante e feto; acidentes laboratoriais; e, por fim, menos comum, por via oral (Baliza, Tozetto, Oliveira & Sotolani, 2018;Ferreira, Branquinho & Cardarelli-Leite, 2014;G. G. e Silva, Aviz & Monteiro, 2020).…”

Section: Introductionunclassified

“…A transmissão pela via oral pode ocorrer por ingestão de material contaminado com Research, Society and Development, v. 9, n. 10, e8449109120, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i10.9120 triatomíneos infectados ou suas fezes, ingestão de carne crua ou mal cozida ou ainda pelas secreções de alguns mamíferos infectados (Ferreira et al, 2014).…”

Section: Introductionunclassified

Epidemiologia da Doença de Chagas aguda no Brasil de 2007 a 2018

Alencar

Filho

Hirschheiter

et al. 2020

RSD

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Objetivo: analisar o panorama da Doença de Chagas Aguda, um fim de elucidar questões públicas relacionadas à incidência nas regiões brasileiras ao longo dos anos, além de trazer informações sobre a temática, inter-relacionando os determinantes sociais aos aspectos relevantes à saúde. Metodologia: Trata-se de um estudo epidemiológico descritivo, baseado em dados do Sistema de Informação de Agravos Notificáveis, dos casos notificados desta doença no período de 2007 a 2018. As taxas foram calculadas no programa estatístico R, versão 3.6.3. Resultados: No período estudado, foram registrados, no país, 2.708 casos confirmados de Doença de Chagas Aguda, com média anual de 225,33 casos, influências maiores nos anos de 2016 e 2018 (1,71 e 1,73 casos por 100.000 habitantes, respectivamente). As maiores taxas de incidência ao longo dos anos ocorreram na Região Norte, onde apresenta 94,87% do total de casos. Os mais acometidos foram os do sexo masculino (53,6%), na faixa etária de 20 a 39 anos (33,4%), e de cor parda (n = 2059, 76%). Conclusão: Diante disso, uma análise dos dados epidemiológicos de extrema importância, pois possibilitam a constatação de que apesar das iniciativas governamentais em vistas de prevenir esta doença nas diversas regiões do Brasil, sobretudo na região Norte, onde um contato ainda prevalece alta

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Transmissão oral da doença de Chagas pelo consumo de açaí: um desafio para a Vigilância Sanitária

Cited by 8 publications

References 0 publications

Retrospective study of the epidemiological overview of the transmission of Chagas disease in the State of Acre, South-Western Amazonia, from 2009 to 2016

Retrospective study of the epidemiological overview of the transmission of Chagas disease in the State of Acre, South-Western Amazonia, from 2009 to 2016

Modeling the impact of xenointoxication in dogs to haltTrypanosoma cruzitransmission

Epidemiologia da Doença de Chagas aguda no Brasil de 2007 a 2018

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