Transmisión materno-fetal de Trypanosoma cruzi, un problema de salud poco estudiado en México: caso Chiapas

Campos-Valdéz, Guillermina; Canseco-Ávila, Luisa Miguel; González-Noriega, Fernando; Alfaro-Zebadua, Oscar; Nava-Medecigo, Ismael Yadird; Jiménez-Cardoso, Enedina

doi:10.21149/spm.v58i3.7898

Cited by 8 publications

(2 citation statements)

References 19 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cases suggest the possible and potential urbanization of asymptomatic CD, randomly transmitted through vertical pathway inside a nuclear autochthonous Mayan family in Chiapas in absence of the vector. This fact could be supported by previous evidence, have demonstrated a vertical transmission incidence ranged between 7 to 22% in two different areas from Chiapas, Mexico, where the mother and newborn were asymptomatic ( 13 – 15 ).…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Aleatory Trypanosoma cruzi Vertical Transmission in Chiapas, Mexico: A Case Report

López-Cancino¹,

Méndez-Gálvan²,

Soria-Guerrero³

et al. 2021

IJPA

Self Cite

View full text Add to dashboard Cite

Congenital Chagas disease is considered a form of dispersion of Trypanosoma cruzi related to human migration from endemic, often rural to previously non-endemic urban areas. This fact increases the Chagas disease establishment risk inside of family members by vertical transmission pathway. Congenital Chagas disease cases in newborns could not identified by the health professional even in endemic regions. Here we present the first family cluster of Chagas disease cases from Chiapas: one of the most important endemic areas in South of Mexico, where vertical T. cruzi transmission incidence rate is ranged between 2% to 22% revealing an important public health problem. Two cases inside a family from Chiapas, México with positive antibodies against T. cruzi detected by ELISA are presented; one of them got the infection through vertical pathway. We think that congenital Chagas disease should not be ignored in a newborn born from an asymptomatic Chagas disease mother, who may transmit the parasite infection randomly.

show abstract

Section: Discussionsupporting

confidence: 81%

“…The first report of a congenitally transmitted case of CD occurring in Mexico was in 1998 ( 12 ). The congenital CD epidemiology in Chiapas is estimated from 7% to 22% in urban settlements (there are not estimations for congenital CD to rural areas) ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Aleatory Trypanosoma cruzi Vertical Transmission in Chiapas, Mexico: A Case Report

López-Cancino¹,

Méndez-Gálvan²,

Soria-Guerrero³

et al. 2021

IJPA

Self Cite

View full text Add to dashboard Cite

show abstract

Maternal infection and stillbirth: a review

McClure

Silver

Kim

et al. 2020

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

Estimating the current burden of Chagas disease in Mexico: a systematic review of epidemiological surveys from 2006 to 2017

Arnal

Waleckx

Herrera

et al. 2018

Preprint

View full text Add to dashboard Cite

BackgroundIn Mexico, estimates of Chagas disease prevalence and burden vary widely. Updating surveillance data is therefore an important priority to ensure that Chagas disease does not remain a barrier to the development of Mexico’s most vulnerable populations.Methodology/Principal FindingsThe aim of this systematic review was to analyze the literature on epidemiological surveys to estimate Chagas disease prevalence and burden in Mexico, during the period 2006 to 2017. A total of 2,764 articles were screened and 38 were retained for the final analysis. Epidemiological surveys have been performed in most of Mexico, but with variable geographic coverage. Based on studies reporting confirmed cases, i.e. using at least 2 serological tests, the national seroprevalence of Trypanosoma cruzi infection was 2.26% [95% Confidence Interval (CI) 2.12-2.41], suggesting that there are 2.71 million cases in Mexico. Studies focused on pregnant women, which may transmit the parasite to their newborn during pregnancy, reported a seroprevalence of 1.00% [95% CI 0.87-1.14], suggesting that there are 22,930 births from T. cruzi infected pregnant women per year, and 1,445 cases of congenitally infected newborns per year. Children under 18 years had a seropositivity rate of 1.49% [95% CI 1.20-1.85], which indicate ongoing transmission. Finally, cases of T. cruzi infection in blood donors have also been reported in most states, with a national seroprevalence of 0.51% [95% CI 0.49-0.53].Conclusions/SignificanceOur analysis suggests a disease burden for T. cruzi infection higher than previously recognized, highlighting the urgency of establishing Chagas disease surveillance and control as a key national public health priority in Mexico, to ensure that it does not remain a major barrier to the economic and social development of the country’s most vulnerable populations.Author summaryIn Mexico, estimates of Chagas disease prevalence and burden vary widely due to the ecology and epidemiology of this disease resulting of many geographical, ecological, biological, and social interactions. Better data are thus urgently needed to help develop appropriate public health programs for disease control and patient care. In this study we analyzed published data on T. cruzi seroprevalence infection in Mexico between 2006 and 2017. This systematic review shows a national seroprevalence of T. cruzi infection of 2.26% [95%CI 2.12-2.41], with over 2.71 million cases in Mexico, which is higher than previously recognized. The presence of T. cruzi infection in specific subpopulations such as pregnant women, children and blood donors also informs on specific risks of infection and call for the implementation of well-established control interventions. This work confirms the place of Mexico as the country with the largest number of cases, highlighting the urgency of establishing Chagas disease control as a key national public health priority.

show abstract

Transmisión materno-fetal de Trypanosoma cruzi, un problema de salud poco estudiado en México: caso Chiapas

Cited by 8 publications

References 19 publications

Aleatory Trypanosoma cruzi Vertical Transmission in Chiapas, Mexico: A Case Report

Aleatory Trypanosoma cruzi Vertical Transmission in Chiapas, Mexico: A Case Report

Maternal infection and stillbirth: a review

Estimating the current burden of Chagas disease in Mexico: a systematic review of epidemiological surveys from 2006 to 2017

Contact Info

Product

Resources

About