Transmetatarsal Amputation in the Setting of Antiphospholipid Antibody Syndrome

McLeod, Jacob M.; Brantigan, Charles O.; Alix, Kristen; Kruse, Dustin; Stone, Paul A.

doi:10.1053/j.jfas.2013.02.011

Cited by 2 publications

(2 citation statements)

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“…Appropriate perioperative management is imperative in these patients because lifeand limb-threatening complications can occur postoperatively despite aggressive anticoagulation. The surgical management of the patients with APS should be performed as if they had vascular thrombosis, and perioperative anticoagulation should be maintained [7]. As in the present case, in minor surgical procedures, the application of topical hemostatic devices such as gelatin sponges has been shown to be effective.…”

Section: Discussionmentioning

confidence: 64%

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Hallux Partial Necrosis Associated with Antiphospholipid Syndrome: The Importance of Early Accurate Diagnosis

Córdoba-Fernández

Mármol-García

Córdoba-Jiménez³

2023

Life

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This study highlights the importance of having a high clinical suspicion of hypercoagulopathy such as antiphospholipid syndrome (APS) in podiatric patients with normal foot pulses and normal standard coagulation tests.APS is an autoimmune disease that is characterized by inflammatory thrombosis in the arteries and veins and obstetric complications such as pregnancy loss. APS usually affects vessels of the lower extremities. We report herein the case of a 46-year-old woman with previous episodes of pre-eclampsia who suffered from partial ischemic necrosis of the hallux of the left foot. After several ischemic episodes of the hallux, with increased risk of toe amputation, the patient was finally diagnosed with APS and treated with specific anticoagulant medication. The patient’s symptoms subsided, and toe amputation was prevented. Early accurate diagnosis and appropriate clinical management are critical to providing optimal outcomes and reducing the risk of amputation.

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Section: Discussionmentioning

confidence: 64%

“…APS is a hypercoagulable disorder in which patients usually present with some type of venous or arterial thrombosis that usually affects the vessels of the lower extremities [5][6][7][8]. APS usually presents alone but can occur in the presence of other autoimmune diseases, commonly systemic lupus erythematosus.…”

Section: Discussionmentioning

confidence: 99%