Transmembrane 163 (TMEM163) protein interacts with specific mammalian SLC30 zinc efflux transporter family members

Pan-cancer analysis of TMEM45A indicates its potential prognostic value and functional validation in gastric cancer

“…For example, in asthma, the activation of TMEM16A by in ammatory mediators makes airway smooth muscle (ASM) more sensitive to cholinergic stimulation, and this sensitivity is an important factor in the development of airway hyperreactivity [13,14] .In head and neck squamous cell carcinoma (HNSCC), combination therapy with TMEM16A and PD-L1 inhibitors improves survival in patients with HNSCC, especially those resistant to epidermal growth factor receptor (EGFR) inhibitors [15] .TMEM196 inhibits the Wnt signaling pathway and suppresses β-cyclin promoter transcription to strongly inhibit lung cancer metastasis and progression in vivo and in vitro [16] . TMEM163 has been reported to be a zinc e ux transporter protein with physiologically relevant interactions with solute carrier 30 (SLC30), and their heterodimerization may contribute to the functional diversity of zinc e ux in speci c tissues or cell types, which has led to the association of TMEM163 directly or indirectly with a wide range of human diseases, such as Parkinson's disease, type IV mucolipidosis and diabetes [17][18][19] .TMEM175 has been shown to be a genetic risk factor for Parkinson's disease (PD), mediating lysosomal H [+] leakage by acting as a proton-activated,proton-selective channel on the lysosomal membrane (LyPAP).De ciency of TMEM175 leads to lysosomal over-acidi cation, impaired protein hydrolysis, and promotes the aggregation of α-synuclein in vivo, which results in the loss of lysosomal normal function [20] .…”