Abstract:Recently, we reported that TMEM163 is a zinc efflux transporter that likely belongs to the mammalian solute carrier 30 (Slc30/ZnT) subfamily of the cation diffusion facilitator (CDF) protein superfamily. We hypothesized that human TMEM163 forms functional heterodimers with ZNT proteins based on their subcellular localization overlapping with TMEM163 and previous reports that certain ZNT monomers interact with each other. In this study, we heterologously expressed individual constructs with a unique peptide tag… Show more
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