Transmanubrial osteomuscular sparing approach for resection of cervico-thoracic lesions

Pan, Xufeng; Gu, Chang; Wang, Rui; Zhao, Heng; Yang, Jun; Shi, Jianxin

doi:10.21037/jtd.2017.08.99

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…Giant tumors of the CTJ, which are located at the junction of the neck and mediastinum, are mostly caused by the upward growth of mediastinal tumors into the cervical root or the downward growth of cervical root tumors into the mediastinum (10)(11)(12). Surgical resection is the first-choice treatment for giant tumors of the CTJ (13,14).…”

Section: Discussionmentioning

confidence: 99%

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Reverse “L” surgical approach for the management of giant tumors of the cervicothoracic junction

Zhong¹,

Yang²,

Jiang³

et al. 2020

J Thorac Dis

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Background: An isolated cervical or thoracic surgical approach provides insufficient exposure for achieving complete resection of tumors of the cervicothoracic junction. This study examines reverse "L" thoracotomy as a surgical approach to these tumors. Additionally, the feasibility, safety, and effectiveness of reverse "L" surgical incision for tumor resection was also analyzed.Methods: Patients with cervicothoracic tumors were identified from an internal database. Subjects were selected on the basis of undergoing reverse "L" thoracotomy from August 2014 to August 2018. The tumor characteristics, surgical technique, completeness of resection, morbidity, and patient outcome were reviewed.Results: All patients successfully underwent resection through reverse "L" surgical approach. No patients needed to undergo full sternotomy. There were 6 neurogenic tumors, 4 thyroid adenocarcinomas, 4 bronchogenic tumors, and 7 other cases in the study. The median operative time was 191.0 min (range, 113.0-348.0 min) and postoperative in-hospital stay ranged from 3 to 7 days. Horner syndrome was observed in 1 case. Hoarseness and lymphatic leakage were evident in 3 and 1 case(s), respectively. Hemidiaphragm paralysis was observed in 1 case. Three cases were unsuccessful in achieving R0 resection. The duration of follow-up ranged from 6 to 42 months. Eleven of 13 patients who underwent resection had no evidence of tumor recurrence. Two patients with metastatic disease died of distant progression within 15 months.Conclusions: Applying reverse "L" surgical approach is safe, feasible, and effective for the resection of giant tumors of the cervicothoracic junction.

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Section: Discussionmentioning

confidence: 99%

“…Many surgeons adopt the transmanubrial osteomuscular sparing approach (TMA) as one of several methods applied to the CTJ tumor resection. TMA has been reported to preserve the sternoclavicular joint without shoulder deformity (10). However, TMA is mostly limited to tumors extending from the mediastinum to the neck.…”

Section: Original Articlementioning

confidence: 99%

Reverse “L” surgical approach for the management of giant tumors of the cervicothoracic junction

Zhong¹,

Yang²,

Jiang³

et al. 2020

J Thorac Dis

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“…The data were analyzed by SPSS 20.0 (SPSS, Chicago, IL, United States). Results were displayed as mean ± standard deviation ( Pan et al, 2017 ; Sun et al, 2017 ). At least three biological replicates were performed for each group of experiments.…”

Section: Methodsmentioning

confidence: 99%

Long Non-coding RNA FIRRE Acts as a miR-520a-3p Sponge to Promote Gallbladder Cancer Progression via Mediating YOD1 Expression

Wang

et al. 2021

Front. Genet.

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ObjectivesThe role of lncRNAs in gallbladder cancer (GBC) remains poorly understood. In this study, we explored the function of functional intergenic repeating RNA element (FIRRE) in GBC.Materials and MethodsWhole transcriptome resequencing was performed in three pairs of GBC tissues and adjacent non-tumor tissues. lncRNA FIRRE expression was verified by real-time PCR. The function of FIRRE in GBC was evaluated by experiments in vitro and in vivo. The mechanism of FIRRE was investigated via fluorescent in situ hybridization, RNA pull-down, dual luciferase reporter assays, and RNA immunoprecipitation.ResultsFIRRE level was dramatically increased in GBC tissues compared to that in the adjacent non-tumor tissues. High expression of FIRRE was closely related to clinical stage and poor prognosis in GBC patients. Moreover, FIRRE remarkably enhanced proliferation and migration, and inhibited apoptosis of GBC cells. Mechanistically, FIRRE modulated YOD1 expression by sponging miR-520a-3p, thus contributing to the development of GBC.ConclusionOur data revealed that FIRRE might act as a novel mediator in GBC progression by sponging miR-520a-3p and regulating YOD1. FIRRE might be regarded as a potential diagnostic marker or target for GBC treatment.

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“…Correlations between miR-101-3p and EZH2 were tested using Pearson's correlation coefficient analysis. All data were examined and statistically significant at P < 0.05 [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

miR-101-3p Serves as a Tumor Suppressor for Renal Cell Carcinoma and Inhibits Its Invasion and Metastasis by Targeting EZH2

Dong

Gao

Xie

et al. 2021

BioMed Research International

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Background. The role of miRNAs in renal cell carcinoma (RCC) is not certain. We wanted to study the biological functions and potential mechanisms of miR-101-3p in RCC. Methods. miR-101-3p was inhibited in A498 and OSRC-2 (two RCC cell lines). We studied its effect on cell invasion and proliferation. Target EZH2 of miR-101-3p was designated by different methods, including luciferase functional analysis and Western blotting. The expression level of the target gene in treated cells was quantitatively analyzed by quantitative real-time polymerase chain reaction. In addition, induction of miR-101-3p to prevent tumor formation of A498 cells in mice was further studied. Results. The overexpression of miR-101-3p significantly inhibited the proliferation, migration, and invasion in two RCC cells. Western blotting and luciferase functional analysis indicated that miR-101-3p regulated the expression of EZH2 in two cell lines. Mice inoculated with A498 and OSRC-2 cells transfected with miR-101-3p mimics showed significantly smaller xenografts and weaker EZH2 expression levels than the control group. Conclusions. miR-101-3p inhibited RCC cell proliferation, migration, and invasion by targeting EZH2.

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Transmanubrial osteomuscular sparing approach for resection of cervico-thoracic lesions

Abstract: TMA can be carried out safely in treating various cervico-thoracic lesions with good resection rate. Left side procedure should be cautious of thoracic duct injury.

Cited by 10 publications

References 21 publications

Reverse “L” surgical approach for the management of giant tumors of the cervicothoracic junction

Reverse “L” surgical approach for the management of giant tumors of the cervicothoracic junction

Long Non-coding RNA FIRRE Acts as a miR-520a-3p Sponge to Promote Gallbladder Cancer Progression via Mediating YOD1 Expression

miR-101-3p Serves as a Tumor Suppressor for Renal Cell Carcinoma and Inhibits Its Invasion and Metastasis by Targeting EZH2

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