Translocation t(Y;14)(q12;q11): A New Abnormality Associated with r[i(8)(q10)] in T-Prolymphocytic Leukemia Studied by Classic Cytogenetics and Spectral Karyotype.
Abstract:T-cell prolymphocytic leukemia (T-PLL) is a malignant proliferation of lymphoid cells with a mature postthymic phenotype. The disease is characterized by lymphadenopathy, splenomegaly, skin lesions, and elevated white blood cell count, and it is often resistant to conventional therapy. Classic cytogenetic studies have revealed the presence of complex karyotypes and some recurrent chromosomal abnormalities, of which the most frequent are t(14;14)(q11;q32), inv(14)(q11q32), t(X;14)(q28;q11), i(8)(q10), and t(8;8… Show more
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