Translocation of Phospholipids Between the Endoplasmic Reticulum and Mitochondria in Yeast

Tuller, Gabriele; Achleitner, Georg; Gaigg, Barbara; Krasser, Anja; Kainersdorfer, Elvira; Kohlwein, Sepp-Dieter; Perktold, Andreas; Zellnig, Günther; Daum, Günther

doi:10.1007/978-3-642-51463-0_30

Cited by 1 publication

(2 citation statements)

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“…1,54,77 As was shown for mammalian MAM, 238 proteolytic treatment of yeast mitochondria negatively affected translocation of PtdSer. 275 Fusogenic proteins similar to those described for mammalian cells by Corazzi's group 33,211 and which are partially inactivated by exogenous proteases, may be involved in this process. None of the putative components, however, has been characterized on a molecular level, neither have the respective genes been identified.…”

Section: Subcellular Location Of Phospholipids Sites Of Synthesis and General Aspects Of Phospholipid Transportmentioning

confidence: 83%

“…Membrane association was suggested as a prerequisite for PtdSer transport from the endoplasmic reticulum to mitochondria. 1,77,275 Most likely, surface proteins of the organelle(s) are involved in this process, although they have not yet been characterized at a molecular level. A second PtdSer decarboxylase present in the Golgi/ vacuolar compartment 268,270 also requires PtdSer from the endoplasmic reticulum.…”

Section: Phospholipid Synthesismentioning

confidence: 99%

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Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae

Daum

Lees

Bard

et al. 1998

Yeast

579

380

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The yeast Saccharomyces cerevisiae is a powerful experimental system to study biochemical, cell biological and molecular biological aspects of lipid synthesis. Most but not all genes encoding enzymes involved in fatty acid, phospholipid, sterol or sphingolipid biosynthesis of this unicellular eukaryote have been cloned, and many gene products have been functionally characterized. Less information is available about genes and gene products governing the transport of lipids between organelles and within membranes, turnover and degradation of complex lipids, regulation of lipid biosynthesis, and linkage of lipid metabolism to other cellular processes. Here we summarize current knowledge about lipid biosynthetic pathways in S. cerevisiae and describe the characteristic features of the gene products involved. We focus on recent discoveries in these fields and address questions on the regulation of lipid synthesis, subcellular localization of lipid biosynthetic steps, cross‐talk between organelles during lipid synthesis and subcellular distribution of lipids. Finally, we discuss distinct functions of certain key lipids and their possible roles in cellular processes. © 1998 John Wiley & Sons, Ltd.

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Section: Subcellular Location Of Phospholipids Sites Of Synthesis and General Aspects Of Phospholipid Transportmentioning

confidence: 83%

Section: Phospholipid Synthesismentioning

confidence: 99%

Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae

Daum

Lees

Bard

et al. 1998

Yeast

579

380

View full text Add to dashboard Cite

show abstract

Translocation of Phospholipids Between the Endoplasmic Reticulum and Mitochondria in Yeast

Cited by 1 publication

References 20 publications

Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae

Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae

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