Translocation of intranasal (i.n.) instillation of different-sized cerium dioxide (CeO₂) particles: potential adverse effects in mice

Effect on Mouse Liver Morphology of CeO2, TiO2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously

“…Pyknosis of single hepatocytes was previously observed after single intratracheal exposure to TiO 2 and carbon black nanoparticles [76], and focal liver necrosis was reported after relatively high intravenous doses (645 mg/kg bw and above) of TiO 2 nanoparticles [57]. To our knowledge, pyknosis and necrosis have not been reported previously for CeO 2 nanoparticles [11,58,71,73,80,81], However, increased apoptosis of hepatocytes induced by CeO 2 nanoparticles was reported [74]. This finding is supportive of our observation of increased pyknosis.…”

“…Its presence on day 28 in the intratracheal CeO 2 group corroborates with the increased incidence of single-cell pyknosis at that time point. Hydropic degeneration of hepatocytes was also reported after translocation of CeO 2 nanoparticles from the lung after intratracheal exposure in mice or in rats [73,80].…”

A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs

“…Inhalation is considered the most important exposure route from an occupational perspective. However, only 4 inhalation study were conducted over the last 5 years in which hepatic effects were determined (Adamcakova-Dodd et al 2014;Gosens et al 2016;Guo et al 2020a;Liu et al 2019), suggesting that this remains a gap in knowledge. Short term IT studies suggest that NMs have the potential to induce acute impacts on liver mostly notable in terms of changes in serum biochemistry associated with liver damage and DNA damage (Wallin et al 2017;Yu et al 2018).…”