Translocation Homozygotes in the Yellow Fever Mosquito, Aedes aegypti

Lorimer, Nancy; Hallinan, E.; S., K.

doi:10.1093/oxfordjournals.jhered.a108261

Cited by 32 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extensive work has been done since then in isolating translocations and evaluating their suitability for genetic control purposes in the laboratory and by computer simulation studies (McDonald & Rai, 1971). The advantages of using translocation homozygotes have been emphasized by Lorimer et al (1972) and crossing homozygous lines allows mass production of double heterozygotes, which in some cases show high sterility, as has been reported by and Uppal et al (1974).…”

Section: Introductionmentioning

confidence: 85%

See 1 more Smart Citation

Sex ratio distorter-translocation homozygotes in Aedes aegypti

Suguna¹,

Kazmi²,

Curtis³

1977

Genetica

View full text Add to dashboard Cite

Two sex ratio distorter-translocation homozygotes were synthesized. In one case there was an enhanced level of sex ratio distortion and the distorter-single translocation heterozygotes did not exhibit uniform semi-sterility and pseudolinkage of marker genes, whereas in the other, fertility and pseudo-linkage remained as expected but sex ratio distortion was reduced. The potential of these two systems for genetic control ofAe. aegypti is discussed.

show abstract

Section: Introductionmentioning

confidence: 85%

“…These are designated T1/T1 and T3/T3 and were made available to this Unit from the University of Notre Dame, Indiana, U.S.A. The T1 was induced in the Rock genome (Lorimer et al, 1972) and re-isolated after repeated backcrosses of both sexes to the Delhi strain. The T3 was induced directly in the Delhi strain .…”

Section: Methodsmentioning

confidence: 99%

Sex ratio distorter-translocation homozygotes in Aedes aegypti

Suguna¹,

Kazmi²,

Curtis³

1977

Genetica

View full text Add to dashboard Cite

show abstract

“…This is partially because the genetically modified homozygous individuals suffered from dramatically reduced fitness relative to wildtypes (e.g. Foster et al (1972); Lorimer et al (1972); Boussy (1988) and references therein; see also Harewood et al (2010)). However, with new, more precise molecular genetic technologies, there is a growing interest in systems, including underdominance, that have the capacity to transform wild populations (Davis et al, 2001;Sinkins and Gould, 2006;Magori and Gould, 2006;Gould, 2008).…”

Section: Overviewmentioning

confidence: 99%

Using underdominance to bi-stably transform local populations

Altrock

Traulsen

Reeves

et al. 2010

Journal of Theoretical Biology

106

View full text Add to dashboard Cite

Underdominance refers to natural selection against individuals with a heterozygous genotype. Here, we analyse a single-locus underdominant system of two large local populations that exchange individuals at a certain migration rate. The system can be characterized by fixed points in the joint allele frequency space. We address the conditions under which underdominance can be applied to transform a local population that is receiving wildtype immigrants from another population. In a single population, underdominance has the benefit of complete removal of genetically modified alleles (reversibility) and coexistence is not stable. The two population system that exchanges migrants can result in internal stable states, where coexistence is maintained, but with additional release of wildtype individuals the system can be reversed to a fully wildtype state. This property is critically controlled by the migration rate. We approximate the critical minimum frequency required to result in a stable population transformation. We also concentrate on the destabilizing effects of fitness and migration rate asymmetry. Practical implications of our results are discussed in the context of utilizing underdominance to genetically modify wild populations. This is of importance especially for genetic pest management strategies, where locally stable and potentially reversible transformations of populations of disease vector species are of interest.

show abstract

“…If insects homozygous for a translocation are introduced into a population at high frequency, they are predicted to spread to fixation [6], and if the translocation is linked to a disease-refractory gene, it is predicted to consequently be driven into the population as well. Initial field trials with translocations were unsuccessful in demonstrating spread [7]; but this is likely a result of those translocations being generated using X-rays, which often induce high fitness costs.…”

Section: Early Inspirationmentioning

confidence: 99%

“…As the first gene drive system to be proposed [4], translocations have since undergone a lull in interest following the observation that radiationgenerated translocations failed to spread in the field, likely due to high fitness costs induced by X-rays [7]. However, recent developments in molecular biology permit the creation of translocations without relying upon radiation suggesting that, after several decades of inactivity, the application of this gene drive system could be revisited.…”

Section: Translocationsmentioning

confidence: 99%