Translocation, Deletion/Amplification, and Expression of HMGIC and MDM2 in a Carcinoma ex Pleomorphic Adenoma

Röijer, Eva; Nordkvist, Anders; Ström, Anna-Karin; Ryd, Walter; Behrendt, Margareta; Bullerdiek, Jörn; Mark, Joachim; Stenman, Göran

doi:10.1016/s0002-9440(10)64862-6

Cited by 86 publications

(64 citation statements)

References 38 publications

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“…Our findings, in addition to previous reports, suggest that copy number gain and amplification of PLAG1 may contribute to malignant progression in a subset of tumors. Amplification and overexpression of HMGA2 has also been postulated in transformation to CA-ex-PA [39]. It seems more likely that malignant degeneration may be triggered by a variety of mechanisms, rather than a single genetic event responsible for all tumors.…”

Section: Discussionmentioning

confidence: 99%

PLAG1 Alteration in Carcinoma Ex Pleomorphic Adenoma: Immunohistochemical and Fluorescence In Situ Hybridization Studies of 22 Cases

Bahrami

Dalton

Bangalore

et al. 2012

Head and Neck Pathol

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Section: Discussionmentioning

confidence: 99%

PLAG1 Alteration in Carcinoma Ex Pleomorphic Adenoma: Immunohistochemical and Fluorescence In Situ Hybridization Studies of 22 Cases

Bahrami

Dalton

Bangalore

et al. 2012

Head and Neck Pathol

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“…21 Compared to PA, subsets of Ca-ex-PA also show amplification of human homolog of mouse double minute 2 gene, mutations of tumor protein p53 gene (TP53), and amplification of human epidermal growth factor receptor 2 gene (HER2/neu) as molecular markers of malignant transformation. 22 Changes in the expression levels of Ki-67, cyclin E, and p63 are also proposed to differentiate PA from Ca-ex-PA. 23 …”

Section: Review Of Ancillary Findings In Various Salivary Gland Neoplmentioning

confidence: 99%

Fine-Needle Aspiration Biopsy of Salivary Gland Lesions

Wang

Fundakowski²,

Khurana³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Fine-needle aspiration (FNA) is a well-established diagnostic approach for salivary gland lesions; however, lack of a standard system of terminology for classification of salivary gland neoplasms collected by FNA and the relatively high frequency of uncertainty of diagnosis are likely partly responsible for current confusion in the interpretation of these FNA samples.Objective.-To propose a novel classification system for reporting salivary gland FNA samples and summarize recent progress in application of molecular and immunohistochemical markers in selected salivary gland neoplasms.Data Sources.-Literature review and authors' personal practice experience.Conclusions.-The new classification system provides a more succinct, standardized interpretation of results and will ultimately assist in communication between clinicians, clinical decision making, and preoperative patient counseling. Impressive advances have been made in recent years in the understanding of molecular pathogenesis of salivary gland tumors. With the newly acquired diagnostic tools, significant improvement in diagnostic accuracy of salivary gland FNA can certainly be expected.(Arch Pathol Lab Med. 2015;139:1491-1497; doi: 10.5858/arpa.2015-0222-RA) M asses or cystic lesions of salivary glands have a wide range of differential diagnoses, from inflammatory response to neoplasm and to less common causes of infection.1 The World Health Organization has described 45 morphologic types of primary salivary gland tumors. Fine-needle aspiration (FNA) is a well-established diagnostic approach for salivary gland lesions. Zbaren et al 3 have noted accuracy, sensitivity, and specificity rates for salivary gland FNA of 79% (87 of 110), 74% (50 of 68), and 88% (37 of 42), respectively. Fine-needle aspiration has a higher sensitivity/specificity for benign masses than for malignancy. 4 Carrillo et al 5 also noted that FNA has the potential to change the clinical approach for up to one-third of patients. Salivary lesions remain, however, one of the most challenging entities in cytopathology, mainly because of the diversity of histologic subtypes and the often overlapping morphologic features of the lesions.

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“…Early alterations of chromosomal arm 8q in a PA often involve PLAG1 (8q12.1), an adenoma associated gene, and MYC (8q22.1-q24.1), a known oncogene, resulting in their overexpression [32,33]. However, the malignant transformation of a PA to Ca ex PA can be attributed to the 12q genes, HMGIC, HMGA2 and MDM2.…”

Section: Chromosomal Changesmentioning

confidence: 99%

Carcinoma ex Pleomorphic Adenoma: A Comprehensive Review of Clinical, Pathological and Molecular Data

Antony

Gopalan

Smith

et al. 2011

Head and Neck Pathol

206

243

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Carcinoma ex pleomorphic adenoma (Ca ex PA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma. It often poses a diagnostic challenge to clinicians and pathologists. This study intends to review the literature and highlight the current clinical and molecular perspectives about this entity. The most common clinical presentation of CA ex PA is of a firm mass in the parotid gland. The proportion of adenoma and carcinoma components determines the macroscopic features of this neoplasm. The entity is difficult to diagnose pre-operatively. Pathologic assessment is the gold standard for making the diagnosis. Treatment for Ca ex PA often involves an ablative surgical procedure which may be followed by radiotherapy. Overall, patients with Ca ex PA have a poor prognosis. Accurate diagnosis and aggressive surgical management of patients presenting with Ca ex PA can increase their survival rates. Molecular studies have revealed that the development of Ca ex PA follows a multistep model of carcinogenesis, with the progressive loss of heterozygosity at chromosomal arms 8q, then 12q and finally 17p. There are specific candidate genes in these regions that are associated with particular stages in the progression of Ca ex PA. In addition, many genes which regulate tumour suppression, cell cycle control, growth factors and cell-cell adhesion play a role in the development and progression of Ca ex PA. It is hopeful that these molecular data can give clues for the diagnosis and management of the disease.

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Translocation, Deletion/Amplification, and Expression of HMGIC and MDM2 in a Carcinoma ex Pleomorphic Adenoma

Cited by 86 publications

References 38 publications

PLAG1 Alteration in Carcinoma Ex Pleomorphic Adenoma: Immunohistochemical and Fluorescence In Situ Hybridization Studies of 22 Cases

PLAG1 Alteration in Carcinoma Ex Pleomorphic Adenoma: Immunohistochemical and Fluorescence In Situ Hybridization Studies of 22 Cases

Fine-Needle Aspiration Biopsy of Salivary Gland Lesions

Carcinoma ex Pleomorphic Adenoma: A Comprehensive Review of Clinical, Pathological and Molecular Data

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