Translocation (5;10)(q22;q24) in a case of acute lymphoblastic leukemia

Gough, Sheryl M.; Benjes, Suzanne M.; McDonald, Margaret; Heaton, D. C.; Ganly, Peter; Morris, Christine M.

doi:10.1016/j.cancergencyto.2005.08.008

Cited by 1 publication

(1 citation statement)

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“…PAX2 was also found to be a good marker for metastatic renal cell carcinoma due to its strong nuclear immunoreactivity, as well as its higher sensitivity 3 . Other tumors, including fallopian tube cancer 5 - 7 , breast cancer 8 , ovarian 9 , acute lymphoblastic leukemia 10 , Wilms' tumor 11 , Kaposi's sarcoma 12 and MÜllerian-derived tumors 13 , 14 , all had relationship with PAX2.…”

Section: Introductionmentioning

confidence: 99%

Paired box 2 promotes progression of endometrial cancer via regulating cell cycle pathway

Wang¹,

Nan²,

Lyv³

et al. 2018

J. Cancer

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Background: Human paired box 2 (PAX2) plays a key role in cell fate, early patterning and organogenesis.Methods: We investigated the function of PAX2 on the biological behavior of endometrial cancer in vitro and in vivo and to explore the regulation mechanism, stable knocking-down and over-expression PAX2 endometrial cancer cell lines were established. CCK-8 and transwell assays were applied to determine proliferation, invasion and migration ability. Cell cycle distribution was analyzed by flow cytometry. Affymetrix GeneChip® human Exon 1.0 ST arrays was used to screen the downstream target genes of PAX2.Results: PAX2 significantly enhanced proliferation and invasiveness. In addition, PAX2 influenced the expression of cyclin-dependent kinase 1(CDK1), which play pivotal roles in cell cycle pathway. When CDK1 was knocked down, and the cell proliferation promotion role of PAX2 was attenuated dramatically to a level comparable with the control groups.Conclusions: PAX2, though influencing the expression of CDK1, promotes the proliferation, enhances the mobility of endometrial cancer cells, thus exerts an important role in the carcinogenesis of endometrial cancer. PAX2 may be a potential therapeutic target for endometrial cancer.

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