Translocation (3;21) in Philadelphia-Positive Cml Blast Crisis in a Boy with Severe Skeletal Changes

t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia

“…The present AML with t(3;21)(q26;q22) is unusual for two reasons. First, it occurred in a young boy, and the t(3;21) has previously never been reported in a child, except in a Philadelphia-positive CML in myelomonocytic blast crisis (Mandel et al, 1994). The possibility that the present case was a Philadelphia-negative, but BCR-positive, CML in blast crisis was ruled out because no BCR rearrangement was detected.…”

“…First, it occurred in a young boy, and the t(3;21) has previously never been reported in a child, except in a Philadelphia-positive CML in myelomonocytic blast crisis (Mandel et al, 1994). First, it occurred in a young boy, and the t(3;21) has previously never been reported in a child, except in a Philadelphia-positive CML in myelomonocytic blast crisis (Mandel et al, 1994).…”