Translational Studies in the Complex Role of Neurotransmitter Systems in Anxiety and Anxiety Disorders

Olivier, Jocelien; Olivier, Berend

doi:10.1007/978-981-32-9705-0_8

Cited by 21 publications

(10 citation statements)

References 112 publications

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“…Furthermore, pre-treatment with the benzodiazepine receptor antagonist flumazenil does not counteract these effects of BEO [18], suggesting that neurotransmissions, other than GABAergic, are involved. Particularly, the serotonin system plays an important role in the neural processing of anxiety [34][35][36] and, among the central serotonin receptors (5-HT1-7), the 5-HT1A receptor subtype seems to play a key role in the control of anxiety by influencing serotonergic neurotransmission in multiple brain regions [30,[35][36][37]41]. The latter include the raphe nuclei, where 5-HT1A is expressed as somatodendritic autoreceptor [38], and in other brain regions such as hippocampus and cortex, where this subtype is also expressed as a heteroreceptor on glutamatergic and GABAergic neurons [30,39].…”

Section: Discussionmentioning

confidence: 99%

Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

Rombolà,

Scuteri,

Watanabe

et al. 2020

IJMS

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The essential oil obtained by the fresh fruit of Citrus bergamia Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((±)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests.

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Section: Discussionmentioning

confidence: 99%

Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

Rombolà,

Scuteri,

Watanabe

et al. 2020

IJMS

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“…They are potential and pharmacological targets for anxiety and PTSD. [34,35] HT4R is widely expressed in the whole central nervous system and the periphery and plays an important role in regulating emotion, anxiety, and cognition. The hippocampus specific loss of 5-HT4R will trigger anxiety-like behavior in mice.…”

Section: Discussionmentioning

confidence: 99%

Exploring the potential mechanism of Kaixinsan powder for the same pathogenesis of PTSD and anxiety based on network pharmacology and molecular docking: A review

Li,

Wang,

et al. 2023

Medicine

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Background: Post-traumatic stress disorder (PTSD) and anxiety are common mental illnesses and there are many similar pathogenesis and clinical manifestations between PTSD and anxiety. Kaixinsan powder (KXS), a commonly used prescription in traditional Chinese medicine, has been widely used to treat PTSD and anxiety. This study aims to explore the potential mechanisms of KXS for the same pathogenesis of PTSD and anxiety using a network pharmacology approach. Methods: The bioactive components and relevant target genes of KXS were obtained from the database about Traditional Chinese Medicine. The key genes of PTSD and anxiety were derived from disease databases. Subsequently, the network of protein–protein interaction and a network of “drug-components-disease-targets” was constructed. In order to treat PTSD and anxiety, gene ontology enrichment and signaling pathway enrichment were analyzed by using R language and components-core targets associated were validated by molecular docking. Results: One hundred three targets of KXS in treating PTSD and anxiety were identified. The results of protein–protein interaction analysis and molecular docking indicated that AKT1 and IL-6 were crucial targets. Moreover, KEGG analysis has shown that neuroactive ligand-receptor interaction, calcium signaling pathway, and cAMP signaling pathway may play crucial roles in treating PTSD and anxiety. Ten biological process, 10 molecular function, and 10 cellular component were revealed via gene ontology analysis. Conclusions: The network pharmacology study and molecular docking indicated that KXS treated anxiety and PTSD by multiple components, targets, and signaling pathways. These results provide an important reference for subsequent basic research on PTSD and anxiety.

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“…The hippocampus is related to memory, while the prefrontal cortex is associated with emotions [ 51 , 52 ]. 5-HT and GABA receptors can be used as targets for anti-anxiety drugs [ 53 ]. This finding also suggests that inactivated N1115 improves behavior and cognitive function by regulating these neurotransmitter receptors, acting as a mood drug.…”

Section: Discussionmentioning

confidence: 99%

Heat-inactivated Lacticaseibacillus paracasei N1115 alleviates the damage due to brain function caused by long-term antibiotic cocktail exposure in mice

et al. 2022

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Critical development period of intestinal microbiota occurs concurrently with brain development, and their interaction is influenced by the microbiota–gut–brain axis. This study examined how antibiotics exposure affected gut microbiota and brain development and analyzed the possible benefits of heat-inactivated Lacticaseibacillus paracasei N1115 (N1115). Thirty neonatal male mice were randomly divided into three groups and treated with sterilized water (control), an antibiotic cocktail (Abx), or antibiotics plus heat-inactivated N1115 (Abx + N1115) for 84 days. We found that while the mRNA levels of GABAAα1, GABAb1, and glucocorticoid receptor (GR) in the hippocampus and brain-derived neurotrophic factor (BDNF), GABAAα1, GABAb1, and nerve growth factor (NGF) in the prefrontal cortex were higher, the mRNA levels of 5-HT1A were lower in the Abx group. The Abx + N1115 group had lower mRNA levels of GABAAα1, GABAb1, and GR in the hippocampus and BDNF, GABAb1, and NGF in the prefrontal cortex than the Abx group. The latency period was longer in the Morris water maze test while longer rest time was seen in tail suspension test in the Abx group than the control and Abx + N1115 groups. In the open field test, the moving time and distance of the Abx group were reduced. Further, the alpha-diversity indexes of the Abx and Abx + N1115 groups were significantly lower than the control. Further, long-term exposure to antibiotics disrupted the intestinal microbiota as evidenced by decreased Bacteroides, Firmicutes, and Lactobacillus, and increased Proteobacteria and Citrobacter. However, N1115 significantly decreased the abundance of Citrobacter when compared with those in the Abx group. These results indicate that antibiotics can substantially damage the intestinal microbiota and cognitive function, causing anxiety and depression, which can be alleviated by heat-inactivated N1115 via modulation of the microbiota–gut–brain axis.

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Translational Studies in the Complex Role of Neurotransmitter Systems in Anxiety and Anxiety Disorders

Cited by 21 publications

References 112 publications

Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent

Exploring the potential mechanism of Kaixinsan powder for the same pathogenesis of PTSD and anxiety based on network pharmacology and molecular docking: A review

Heat-inactivated Lacticaseibacillus paracasei N1115 alleviates the damage due to brain function caused by long-term antibiotic cocktail exposure in mice

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