Translational Stroke Research

Bosetti, Francesca; Koenig, James I.; Ayata, Cenk; Back, Stephen A.; Becker, Kyra J.; Broderick, Joseph P.; Carmichael, S. Thomas; Cho, Sunghee; Cipolla, Marilyn J.; Corbett, Dale; Corriveau, Roderick A.; Cramer, Steven C.; Ferguson, Adam R.; Finklestein, Seth P.; Ford, Byron D.; Furie, Karen L.; Hemmen, Thomas; Iadecola, Costantino; Jakeman, Lyn B.; Janis, Scott; Jauch, Edward C.; Johnston, Karen C.; Kochanek, Patrick M.; Kohn, Harold; Lo, Eng H.; Lyden, Patrick D.; Mallard, Carina; McCullough, Louise D.; McGavern, Linda M.; Meschia, James F.; Moy, Claudia S.; Pérez-Pinzón, Miguel A.; Ramadan, Ipolia; Savitz, Sean I; Schwamm, Lee H; Steinberg, Gary K.; Stenzel-Poore, Mary P.; Tymianski, Michael; Warach, Steven; Wechsler, Lawrence R.; Zhang, Junyi; Koroshetz, Walter J.

doi:10.1161/strokeaha.117.017112

Cited by 111 publications

(46 citation statements)

References 23 publications

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“…Although motor impairment accounts for most disability post-stroke, the presence of other common stroke-related impairments adds complexity to initial assessment and goal setting and may influence rehabilitation outcome. Research addressing basic mechanisms of neurological recovery, neuroplasticity-promoting strategies, and novel treatments is being actively conducted [53][54][55][56]. So far, however, rehabilitation remains the standard of care for motor impairment post-stroke [53].…”

Section: Stroke Rehabilitationmentioning

confidence: 99%

The new frontiers of rehabilitation medicine in people with chronic disabling illnesses

Scrutinio

Giardini

Chiovato

et al. 2019

European Journal of Internal Medicine

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Because of the demographic shift and the increased proportion of patients surviving acute critical illnesses, the number of people living with severely disabling chronic diseases and, consequently, the demand for rehabilitation are expected to increase sharply over time. As underscored by the World Health Organization, there is substantial evidence that the provision of inpatient rehabilitation in specialized rehabilitation units to people with complex needs is effective in fostering functional recovery, improving health-related quality of life, increasing independence, reducing institutionalization rate, and improving prognosis. Recent studies in the real world setting reinforce the evidence that patients with ischemic heart disease or stroke benefit from rehabilitation in terms of improved prognosis. In addition, there is evidence of the effectiveness of rehabilitation for the prevention of functional deterioration in patients with complex and/or severe chronic diseases. Given this evidence of effectiveness, rehabilitation should be regarded as an essential part of the continuum of care. Nonetheless, rehabilitation still is underdeveloped and underused. Efforts should be devoted to foster healthcare professional awareness of the benefits of rehabilitation and to increase referral and participation.

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Section: Stroke Rehabilitationmentioning

confidence: 99%

The new frontiers of rehabilitation medicine in people with chronic disabling illnesses

Scrutinio

Giardini

Chiovato

et al. 2019

European Journal of Internal Medicine

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“…To date, intravenous thrombolysis, and thrombectomy are approved efficient therapies for ischemic stroke patients (Lambertsen et al, 2019;Tao et al, 2019;Yang et al, 2019). However, due to the narrow therapeutic time window and a cascade of pathophysiological events induced by reperfusion, the recanalization therapies are only available for a small fraction of stroke patients (Bosetti et al, 2017;Ma et al, 2019). Therefore, novel therapeutic options for cerebral ischemia are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, novel therapeutic options for cerebral ischemia are urgently needed. New treatments targeting key pathogenic mechanisms are currently being explored in the preclinical and clinical stroke research, either alone or in combination with reperfusion therapies (George and Steinberg, 2015;Bosetti et al, 2017). Inflammation is integral to the whole process of stroke pathogenesis, thus serving as a prime target for the development of new stroke therapies (Shao et al, 2019;Zhu et al, 2019), and potentially providing a clinically accessible time window for initiating therapy (Chen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities

Chen

et al. 2020

Front. Cell. Neurosci.

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Post-stroke inflammation is almost involved in the whole process of stroke pathogenesis, which serves as a prime target for developing new stroke therapies. Despite known sex differences in the incidence and outcome of stroke, few preclinical or clinical studies take into account sex bias in treatment. Recent evidence suggests that poly (ADP-ribose) polymerase (PARP)-1 inhibitor exerts sex-specific neuroprotection in the ischemic stroke. This study was aimed to investigate the effects of delayed PARP-1 inhibition on post-stroke inflammation and possible sexual dimorphism, and explore the possible relevant mediators. In male and female C57BL/6 mice subjected to transit middle cerebral artery occlusion (MCAO), we found that delayed treatment of PARP-1 inhibitor at 48 h following reperfusion could comparably alleviate neuro-inflammation at 72 h after stroke. Whereas, more remarkable reduction of iNOS and MMP9 induced by PARP-1 inhibition were found in male MCAO mice, and the improvement of behavioral outcomes was more prominent in male MCAO mice. In addition, we further identified that PARP-1 inhibitor might equivalently suppress microglial activation in males and females in vivo and in vitro. With proteomic analysis and western blotting assay, it was found that stroke-induced peroxiredoxin-1 (Prx1) expression was significantly affected by PARP-1 inhibition. Interestingly, injection of recombinant Prx1 into the ischemic core could block the anti-inflammatory effects of PARP-1 inhibitor in the experimental stroke. These findings suggest that PARP-1 inhibitor has effects on regulating microglial activation and post-stroke inflammation in males and females, and holds promise as a novel therapeutic agent for stroke with extended therapeutic time window. Efforts need to be made to delineate the actions of PARP-1 inhibition in stroke, and here we propose that Prx1 might be a critical mediator.

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“…The adoption of these strategies has been relatively slow and requires continual emphasis and discussion [ 9 ]. Recently, the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institute of Health (NIH) held a conference entitled the “Translational Stroke Research: Vision and Opportunities Workshop” [ 10 ]. This workshop was highly successful in bringing together researchers that could have a high impact on future stroke therapeutics [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical

Bix

Fraser

Mack

et al. 2018

Transl. Stroke Res.

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The first annual Stroke Translational Research Advancement Workshop (STRAW), entitled “Uncovering the Rosetta Stone: Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical” was held at the University of Kentucky on October 4–5, 2017. This workshop was organized by the Center for Advanced Translational Stroke Science. The workshop consisted of 2 days of activities. These included three presentations establishing the areas of research in stroke therapeutics, discussing the routes for translation from bench to bedside, and identifying successes and failures in the field. On day 2, grant funding opportunities and goals for the National Institute for Neurological Diseases and Stroke were presented. In addition, the meeting also included break-out sessions designed to connect researchers in areas of stroke, and to foster potential collaborations. Finally, the meeting concluded with an open discussion among attendees led by a panel of experts.

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Translational Stroke Research

Cited by 111 publications

References 23 publications

The new frontiers of rehabilitation medicine in people with chronic disabling illnesses

The new frontiers of rehabilitation medicine in people with chronic disabling illnesses

Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities

Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical

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