Translational Research in Pancreatic Adenocarcinoma

Alternative splicing, which is a common phenomenon in mammalian genomes, is a fundamental process of gene regulation and contributes to great protein diversity. Alternative splicing events not only occur in the normal gene regulation process but are also closely related to certain diseases including cancer. In this review, we briefly demonstrate the concept of alternative splicing and DNA damage and describe the association of alternative splicing and cancer pathogenesis, focusing on the potential relationship of alternative splicing, DNA damage, and gastrointestinal cancers. We will also discuss whether alternative splicing leads to genetic instability, which is considered to be a driving force for tumorigenesis. Better understanding of the role and mechanism of alternative splicing in tumorigenesis may provide new directions for future cancer studies.

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Translational Research in Pancreatic Adenocarcinoma

Cited by 2 publications

References 10 publications

Computational Analysis of BRCA1 Mutations in Pediatric Patients with Malignancies and Their Mothers

Computational Analysis of BRCA1 Mutations in Pediatric Patients with Malignancies and Their Mothers

Alternative splicing of DNA damage response genes and gastrointestinal cancers

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