Translational repression of the cpw-wpc gene family in the malaria parasite Plasmodium

Abstract

Please cite this article as: Rao Pavitra N., Santos Jorge M., Pain Arnab, Templeton Thomas J., Mair Gunnar R., Translational repression of the cpw-wpc gene family in the malaria parasite Plasmodium, Parasitology International (2016), doi: 10.1016/j.parint.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase‐based mature gametocyte assay

“…These results are in contrast with the recent report that pfs28 upstream and downstream untranslated regions mediate a 50-fold increase in the activity of a plasmid-borne firefly luciferase reporter 24 h after induction of gametogenesis (Rao et al, 2016). This discrepancy is possibly due to the different time after induction of gametogenesis when reporter activity was measured in the other report (Rao et al, 2016) (24 h) and in our experiments (6 h). The increase of Pfs25 production 6 h after gamete formation ( Fig.…”

“…This discrepancy is possibly due to the different time after induction of gametogenesis when reporter activity was measured in the other report (Rao et al ., 2016) (24h) and in our experiments (6h). The increase of Pfs25 production 6h after gamete formation (Fig.…”

Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

“…While genes encoding proteins involved in invasion and gliding motility are assumed to be transcribed and translated when needed, recent studies highlighted many mRNAs encoding motility and invasion proteins to be transcribed and translationally repressed in the female gametocyte, and thus maternally provided to the developing ookinete and oocyst (Ecker et al, 2008; Guerreiro et al, 2014; Santos et al, 2016; Saeed et al, 2013; Rao et al, 2016; Sebastian et al, 2012; Raine et al, 2007). LIMP is one of these factors.…”

Translational Control in the Latency of Apicomplexan Parasites

“…Multiple studies have revealed that specific mRNAs are abundant in latent parasites but are not translated into protein [63,79–87]. These findings indicate that a stable pool of transcripts is maintained in a persistent state of translational repression likely involving a distinct type of cytoplasmic mRNA-containing granule.…”