Translational potential of targeting Anoctamin-1-Encoded Calcium-Activated chloride channels in hypertension

Jimenez, Connor; Hawn, Matthew B.; Akin, Elizabeth J.; Leblanc, Normand

doi:10.1016/j.bcp.2022.115320

Cited by 4 publications

(3 citation statements)

References 173 publications

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“…Flow cytometry studies showed that ANO1 promoted cell proliferation and vascular remodelling by promoting the entry of cells in the G0/G1 phase into the S phase. Previous studies have also shown that ANO1 is involved in the regulation of vascular pressure 93 . Interestingly, in vivo experiments yielded opposite results, with ANO1 being significantly downregulated in the portal vein of PHT rats, which may be related to the involvement of other mechanisms in the regulation of PHT in vivo 32 .…”

Section: Physiological Role Of Ano1 In the Livermentioning

confidence: 89%

“…Previous studies have also shown that ANO1 is involved in the regulation of vascular pressure. 93 Interestingly, in vivo experiments yielded opposite results, with ANO1 being significantly downregulated in the portal vein of PHT rats, which may be related to the involvement of other mechanisms in the regulation of PHT in vivo. 32 Interestingly, in vivo experiments yielded opposite results, with ANO1 expression significantly downregulated in the portal vein of rats with PHT.…”

Section: Physiological Role Of Ano1 In the Livermentioning

confidence: 98%

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The role of anoctamin 1 in liver disease

Li,

Wang,

Zhang

et al. 2024

J Cellular Molecular Medi

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Liver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium‐activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional regulation as well as in many signalling pathways. It is involved in the genesis, development, progression and/or metastasis of several tumours and other diseases including liver diseases. This paper reviews the role and molecular mechanisms of ANO1 in the development of various liver diseases, aiming to provide a reference for further research on the role of ANO1 in liver diseases and to contribute to the improvement of therapeutic strategies for liver diseases by regulating ANO1.

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Section: Physiological Role Of Ano1 In the Livermentioning

confidence: 89%

Section: Physiological Role Of Ano1 In the Livermentioning

confidence: 98%

The role of anoctamin 1 in liver disease

Li,

Wang,

Zhang

et al. 2024

J Cellular Molecular Medi

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“…The role of TMEM16A in systemic and pulmonary hypertension has been recently reviewed [ 12 , 78 , 79 , 80 ], and some key studies are described above. In general, mean arterial pressure in the long-term (hours to days) is mainly modulated by renal pressure natriuresis and diuresis, and associated modulation of cardiac preload and output.…”

Section: Implications For Therapymentioning

confidence: 99%

The TMEM16A channel as a potential therapeutic target in vascular disease

Al-Hosni,

Kaye,

Choi

et al. 2024

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of review The transmembrane protein 16A (TMEM16A) Ca2+-activated Cl− channel constitutes a key depolarising mechanism in vascular smooth muscle and contractile pericytes, while in endothelial cells the channel is implicated in angiogenesis and in the response to vasoactive stimuli. Here, we offer a critical analysis of recent physiological investigations and consider the potential for targeting TMEM16A channels in vascular disease. Recent findings Genetic deletion or pharmacological inhibition of TMEM16A channels in vascular smooth muscle decreases artery tone and lowers systemic blood pressure in rodent models. Inhibition of TMEM16A channels in cerebral cortical pericytes protects against ischemia-induced tissue damage and improves microvascular blood flow in rodent stroke models. In endothelial cells, the TMEM16A channel plays varied roles including modulation of cell division and control of vessel tone through spread of hyperpolarisation to the smooth muscle cells. Genetic studies implicate TMEM16A channels in human disease including systemic and pulmonary hypertension, stroke and Moyamoya disease. Summary The TMEM16A channel regulates vascular function by controlling artery tone and capillary diameter as well as vessel formation and histology. Preclinical and clinical investigations are highlighting the potential for therapeutic exploitation of the channel in a range of maladaptive states of the (micro)circulation.

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Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles

Kang,

Lee

2024

Exp Mol Med

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A transmembrane (TMEM) protein with an unknown function is a type of membrane-spanning protein expressed in the plasma membrane or the membranes of intracellular organelles. Recently, several TMEM proteins have been identified as functional ion channels. The structures and functions of these proteins have been extensively studied over the last two decades, starting with TMEM16A (ANO1). In this review, we provide a summary of the electrophysiological properties of known TMEM proteins that function as ion channels, such as TMEM175 (KEL), TMEM206 (PAC), TMEM38 (TRIC), TMEM87A (GolpHCat), TMEM120A (TACAN), TMEM63 (OSCA), TMEM150C (Tentonin3), and TMEM43 (Gapjinc). Additionally, we examine the unique structural features of these channels compared to those of other well-known ion channels. Furthermore, we discuss the diverse physiological roles of these proteins in lysosomal/endosomal/Golgi pH regulation, intracellular Ca2+ regulation, spatial memory, cell migration, adipocyte differentiation, and mechanical pain, as well as their pathophysiological roles in Parkinson’s disease, cancer, osteogenesis imperfecta, infantile hypomyelination, cardiomyopathy, and auditory neuropathy spectrum disorder. This review highlights the potential for the discovery of novel ion channels within the TMEM protein family and the development of new therapeutic targets for related channelopathies.

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Translational potential of targeting Anoctamin-1-Encoded Calcium-Activated chloride channels in hypertension

Cited by 4 publications

References 173 publications

The role of anoctamin 1 in liver disease

The role of anoctamin 1 in liver disease

The TMEM16A channel as a potential therapeutic target in vascular disease

Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles

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