Translational large animal model of hibernating myocardium: characterization by serial multimodal imaging

Martínez‐Milla, Juan; Galán‐Arriola, Carlos; Carnero, Manuel; Cobiella, Javier; Pérez-Camargo, Daniel; Bautista-Hernández, Víctor; Rigol, Montserrat; Solanes, Núria; Villena-Gutiérrez, Rocío; Lobo, Manuel; Mateo, Jesús; Vílchez-Tschischke, Jean Paul; Salinas, Belén; Cussó, Lorena; López, Gonzalo Javier; Fuster, Valentín; Desco, Manuel; Sánchez‐González, Javier; Ibáñez, Borja

doi:10.1007/s00395-020-0788-0

Cited by 19 publications

(14 citation statements)

References 41 publications

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“…Given the recent development of deep brain stimulation, Parkinson's, Alzheimer's, and stroke models in the pig [13][14][15] , the tools presented here have the potential to permit ndings from these models to inform the design of novel therapeutic strategies in the treatment of neurological disease. Furthermore the open distribution of our translational imaging and analysis platform will further allow for the neurological phenotyping of disease progression in the cardiac, renal, gastric, hepatic, and vascular disease models already available in the pig [4][5][6][7][8][9][10] . Doing so may provide insight into the adaptive responses and structural reorganization of the cortex initiated by disease in the body and could facilitate the combination of longitudinal studies in pigs and crosssectional studies in clinical subjects.…”

Section: Discussionmentioning

confidence: 99%

“…The pig diverged from humans approximately 80 million years ago, but convergent evolution and an omnivore diet have led to a viscera strikingly similar to that of the human 2,3 . The pig can be genetically modi ed and is already used as a model for cardiac, renal, gastric, hepatic, dermal, vascular, craniofacial surgery, making it an ideal model to investigate the neural correlates of disease in the body [4][5][6][7][8][9][10] . Advances in high resolution non-invasive magnetic resonance imaging (MRI) and surgical methods have led to the development of stroke, deep brain stimulation, Parkinson's and Alzheimer's Disease, traumatic brain injury, and epilepsy models renewing interest in the pig as a neurological model of disease 1,[11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

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A Pig White Matter Atlas and Common Connectivity Space Provide a Roadmap for the Introduction of a New Animal Model in Translational Neuroscience

Mars

et al. 2020

Preprint

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The characterization and definition of homology in the cerebral cortex needed for a species to be adopted as a translational model in neuroscience is a unique challenge given the diverse array of cortical morphology present in the mammalian lineage. Using the domestic pig as an example, we provide a roadmap of how leveraging Magnetic Resonance Imaging of the brain and data-driven tractography can overcome these obstacles and facilitate cortical alignment between distantly related species. In doing so, we created a full platform of neuroimaging tools to be used in the pig, including volumetric and surface templates, a structural white matter atlas, and the establishment of a common connectivity space to facilitate pig-human cortical alignment. Releasing our data and code and our pig-human cortical alignment, we permit researchers already working with the pig to accentuate the clinical relevance and translational capacity of their work. By sharing the intermediate outputs and scripts used to construct our pig-human cortical alignment, we also provide a roadmap to expand the current repertoire of animal models used in neuroscience.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Pig White Matter Atlas and Common Connectivity Space Provide a Roadmap for the Introduction of a New Animal Model in Translational Neuroscience

Mars

et al. 2020

Preprint

Self Cite

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“…Reperfusion causes the platelets to bind neutrophils, promotes the retention of inflammatory cells in the microcirculation [30][31][32], and therefore interferes with the diastolic function of the microcirculation, resulting into decreased blood flow to reperfused myocardium [33][34][35]. In addition, reperfusion-induced endothelial damage exposes the subendothelial collagen, allowing rapid binding of platelets to the surface of the microvascular endothelium through surface adhesion factors [36][37][38]. This cascade of events activates local platelets by releasing platelet factors, leading to microthrombosis and ultimately blocking the blood flow [39][40][41].…”

Section: Pathophysiological Mechanisms Ofmentioning

confidence: 99%

Protective Effect of Nicorandil on Cardiac Microvascular Injury: Role of Mitochondrial Integrity

Jiang

et al. 2021

Oxidative Medicine and Cellular Longevity

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A major shortcoming of postischemic therapy for myocardial infarction is the no-reflow phenomenon due to impaired cardiac microvascular function including microcirculatory barrier function, loss of endothelial activity, local inflammatory cell accumulation, and increased oxidative stress. Consequently, inadequate reperfusion of the microcirculation causes secondary ischemia, aggravating the myocardial reperfusion injury. ATP-sensitive potassium ion (KATP) channels regulate the coronary blood flow and protect cardiomyocytes from ischemia-reperfusion injury. Studies in animal models of myocardial ischemia-reperfusion have illustrated that the opening of mitochondrial KATP (mito-KATP) channels alleviates endothelial dysfunction and reduces myocardial necrosis. By contrast, blocking mito-KATP channels aggravates microvascular necrosis and no-reflow phenomenon following ischemia-reperfusion injury. Nicorandil, as an antianginal drug, has been used for ischemic preconditioning (IPC) due to its mito-KATP channel-opening effect, thereby limiting infarct size and subsequent severe ischemic insult. In this review, we analyze the protective actions of nicorandil against microcirculation reperfusion injury with a focus on improving mitochondrial integrity. In addition, we discuss the function of mitochondria in the pathogenesis of myocardial ischemia.

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“…However, kinds of VSD occluders have been widely used clinically in other countries afterwards, including China [ 7 , 8 ]. In order to demonstrate the safety and performance of VSD occluders in the long run, we focused on patients with at least one-year follow-up after the procedure, since many publications only include short- or middle-term follow-up data [ 6 , 9 , 10 ]. Previous research has shown that the group with the AmplatzerTM Membranous and Muscular VSD occluder in child showed the highest closure rate of 93–95%, perhaps due to a better correlation between the diameter of the VSD and height of the child [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Long-Term Change of Arrhythmias after Transcatheter Closure of Perimembranous Ventricular Septal Defects

Zheng

Lin

Wang

et al. 2021

Cardiology Research and Practice

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Objectives. To observe and analyze the long-term change of different types of arrhythmias after transcatheter closure of perimembranous ventricular septal defect (pmVSD). Methods. We retrospectively collected the data of patients who underwent pmVSD closure in our institution from March 2002 to December 2010. Results. One hundred thirty-nine patients met the inclusion criteria, of which 265 (25.5%) had early arrhythmia. They were classified into two categories: conduction abnormality (191/1039; 18.4%) and origin abnormality (94/1039; 9.0%), including 20 patients with both types of arrhythmias. The median follow-up time was 84.5 months, and 103 patients (103/191; 53.9%) with early conduction block got permanent arrhythmias, while only three patients (3/94; 3.2%) with early anomalous origin arrhythmias still had an abnormal electrocardiogram. Serious arrhythmias (28/1039; 2.7%), including II° atrioventricular block (AVB), III° AVB, and complete left bundle branch block (CLBBB), can appear immediately in the early postoperative period (21 patients) or in the late outset (seven patients) after several months or even years (6 months to 8.3 years). Twenty patients (20/21; 95.2%) with serious arrhythmia in the early postoperative period improved after early treatment, but six patients relapsed or worsened during follow-up. At the endpoint, severe arrhythmia persisted in 13 patients, of which four patients got permanent pacemaker implanted, and one patient with recurrent CLBBB died from heart failure. Conclusions. The probability of delayed CAVB or bundle branch block after VSD closure is low but often occurs several years after surgery. Therefore, long-term ECG follow-up should last for several years or even decades. Serious arrhythmias that appear early after transcatheter pmVSD closure may impose a risk of recurrence although they have been cured already. Close attention should be paid to the changes of cardiac function in patients with CLBBB after VSD closure, and the severity of such arrhythmia should be taken seriously and reexamined.

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Translational large animal model of hibernating myocardium: characterization by serial multimodal imaging

Cited by 19 publications

References 41 publications

A Pig White Matter Atlas and Common Connectivity Space Provide a Roadmap for the Introduction of a New Animal Model in Translational Neuroscience

A Pig White Matter Atlas and Common Connectivity Space Provide a Roadmap for the Introduction of a New Animal Model in Translational Neuroscience

Protective Effect of Nicorandil on Cardiac Microvascular Injury: Role of Mitochondrial Integrity

The Long-Term Change of Arrhythmias after Transcatheter Closure of Perimembranous Ventricular Septal Defects

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