Translational Informatics for Natural Products as Antidepressant Agents

Abstract

Depression, a neurological disorder, is a universally common and debilitating illness where social and economic issues could also become one of its etiologic factors. From a global perspective, it is the fourth leading cause of long-term disability in human beings. For centuries, natural products have proven their true potential to combat various diseases and disorders, including depression and its associated ailments. Translational informatics applies informatics models at molecular, imaging, individual, and population levels to promote the translation of basic research to clinical applications. The present review summarizes natural-antidepressant-based translational informatics studies and addresses challenges and opportunities for future research in the field.

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

“…Depression is a prevalent and debilitating illness that is chronic and recurrent, with common symptoms being slowed thinking and reduced volitional activity ( Singla et al, 2021 ). According to several studies, ZJP can effectively protect against Ang II-induced endothelial inflammation by regulating NF-κB signaling pathway ( Ko et al, 2007 ).…”

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“…Depression is a prevalent and debilitating illness that is chronic and recurrent, with common symptoms being slowed thinking and reduced volitional activity (Singla et al, 2021). According to several studies, ZJP can effectively protect against Ang II-induced endothelial inflammation by regulating NF-κB signaling pathway (Ko et al, 2007).…”