Translational In Vivo Assays in Behavioral Biology
Sarah L. Withey,
Diego A. Pizzagalli,
Jack Bergman
Abstract:The failure of preclinical research to advance successful candidate medications in psychiatry has created a paradigmatic crisis in psychiatry. The Research Domain Criteria (RDoC) initiative was designed to remedy this situation with a neuroscience-based approach that employs multimodal and cross-species in vivo methodology to increase the probability of translational findings and, consequently, drug discovery. The present review underscores the feasibility of this methodological approach by briefly reviewing, … Show more
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