Translational implications of the interactions between hormones and age-related hearing loss

Frisina, Robert D.; Bazard, Parveen; Bauer, Mark A.; Pineros, Jennifer; Liu, Hanjun; Ding, Bo

doi:10.1016/j.heares.2020.108093

Cited by 13 publications

(10 citation statements)

References 77 publications

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“…Therefore, aside from using systemic estrogen as a therapy, localized use may be the better choice to apply estrogen and its derivatives to improve hearing impairment. Some strategies for cochlear drug delivery such as nanoparticles, hydrogels, or micropumps can be the focus of future investigations [ 143 , 144 ].…”

Section: The Effect Of Hormone Therapy On Hearingmentioning

confidence: 99%

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Lien

Yang

2021

IJMS

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The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels.

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Section: The Effect Of Hormone Therapy On Hearingmentioning

confidence: 99%

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Lien

Yang

2021

IJMS

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“…In women, muscle strength starts declining during early postmenopausal ages, earlier than in men [34]. Moreover, testosterone has been reported to have a negative effect on hearing [35]. The diminishing levels of testosterone in the elderly males may help their hearing, compared to the aged females, while muscle strength declines by aging.…”

Section: Plos Onementioning

confidence: 99%

Hearing loss and physical function in the general population: A cross-sectional study

Daimaru

Wagatsuma

2022

PLoS ONE

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Objective Hearing loss is a major public health concern. Higher physical function may be related to the maintenance of hearing acuity. Therefore, this study examined the association between hearing loss and physical function in the general population. Methods This cross-sectional study was conducted with health checkup participants who underwent pure-tone audiometry at a regional health care center in Japan. Information for physical function included handgrip strength, vital capacity (VC), and forced expiratory volume in one second (FEV1). A hearing threshold of >30 dB at 1 kHz and/or >40 dB at 4 kHz in either ear was identified as hearing loss. The characteristics of the subjects were examined with stratification by sex and age group. Multivariable logistic regression analysis was performed to examine the association between hearing loss and physical function with adjustments for age, body mass index and current smoking. Results Among the 4766 study subjects, 56.5% were male. The mean age was 47.7 years (SD: 13.8 years; range: 20–86 years), and the prevalence of hearing loss was 12.8% based on the definition stated above. For females, handgrip strength, VC, and FEV1 showed significant negative associations with hearing loss (multivariable-adjusted OR [95% CI] = 0.691 [0.560–0.852], 0.542 [0.307–0.959], and 0.370 [0.183–0.747], respectively). These associations were not found in males. Conclusions Higher physical function was associated with a lower prevalence of hearing loss among females. This study suggests that it is important to maintain physical function for hearing loss in females. Further studies are required to investigate sex differences in the relationship between physical function and hearing loss in the general population.

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“…Given its critical involvement in aging changes in cochlear function, NKCC1 could be a potential therapeutic target for new ARHL treatments. Provocatively, the chronic treatment of aging CBA/CaJ mice with aldosterone, a natural occurring hormone that declines with age in mammals, prevents certain key aspects of ARHL (relative to aging control mice); i.e., aldosterone hormone therapy improved auditory brainstem response thresholds and improved survival of spiral ganglion neurons via inhibition of age-related downregulation of NKCC1 and apoptotic pathways [ 46 , 47 , 48 , 62 ].…”

Section: Sodium-potassium-chloride Cotransportermentioning

confidence: 99%

Roles of Key Ion Channels and Transport Proteins in Age-Related Hearing Loss

Bazard

Frisina

Acosta

et al. 2021

IJMS

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The auditory system is a fascinating sensory organ that overall, converts sound signals to electrical signals of the nervous system. Initially, sound energy is converted to mechanical energy via amplification processes in the middle ear, followed by transduction of mechanical movements of the oval window into electrochemical signals in the cochlear hair cells, and finally, neural signals travel to the central auditory system, via the auditory division of the 8th cranial nerve. The majority of people above 60 years have some form of age-related hearing loss, also known as presbycusis. However, the biological mechanisms of presbycusis are complex and not yet fully delineated. In the present article, we highlight ion channels and transport proteins, which are integral for the proper functioning of the auditory system, facilitating the diffusion of various ions across auditory structures for signal transduction and processing. Like most other physiological systems, hearing abilities decline with age, hence, it is imperative to fully understand inner ear aging changes, so ion channel functions should be further investigated in the aging cochlea. In this review article, we discuss key various ion channels in the auditory system and how their functions change with age. Understanding the roles of ion channels in auditory processing could enhance the development of potential biotherapies for age-related hearing loss.

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Translational implications of the interactions between hormones and age-related hearing loss

Cited by 13 publications

References 77 publications

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

Hearing loss and physical function in the general population: A cross-sectional study

Roles of Key Ion Channels and Transport Proteins in Age-Related Hearing Loss

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