Translational implications of newly characterized pathogenic pathways in systemic lupus erythematosus

Gatto, Mariele; Depascale, Roberto; Stefanski, Ana Luisa; Schrezenmeier, Eva; Dörner, Thomas

doi:10.1016/j.berh.2023.101864

Best Practice & Research Clinical Rheumatology

2023

DOI: 10.1016/j.berh.2023.101864

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Translational implications of newly characterized pathogenic pathways in systemic lupus erythematosus

Mariele Gatto,

Roberto Depascale,

Ana Luisa Stefanski

et al.

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2023

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Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome

Kwon,

Wiedemann,

Steinheuer

et al. 2023

npj Syst Biol Appl

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Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) share clinical as well as pathogenic similarities. Although previous studies suggest various abnormalities in different immune cell compartments, dedicated cell-type specific transcriptomic signatures are often masked by patient heterogeneity. Here, we performed transcriptional profiling of isolated CD4, CD8, CD16 and CD19 lymphocytes from pSS and SLE patients upon T cell stimulation, in addition to a steady-state condition directly after blood drawing, in total comprising 581 sequencing samples. T cell stimulation, which induced a pronounced inflammatory response in all four cell types, gave rise to substantial re-modulation of lymphocyte subsets in the two autoimmune diseases compared to healthy controls, far exceeding the transcriptomic differences detected at steady-state. In particular, we detected cell-type and disease-specific down-regulation of a range of pro-inflammatory cytokine and chemokine pathways. Such differences between SLE and pSS patients are instrumental for selective immune targeting by future therapies.

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Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome

Kwon,

Wiedemann,

Steinheuer

et al. 2023

npj Syst Biol Appl

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show abstract

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Translational implications of newly characterized pathogenic pathways in systemic lupus erythematosus

Cited by 1 publication

References 115 publications

Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome

Transcriptional profiling upon T cell stimulation reveals down-regulation of inflammatory pathways in T and B cells in SLE versus Sjögren’s syndrome

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