Translational control in plant antiviral immunity

Machado, João Paulo; Calil, Iara P.; Santos, Anésia A.; Fontes, Elizabeth P. B.

doi:10.1590/1678-4685-gmb-2016-0092

Cited by 33 publications

(31 citation statements)

References 122 publications

(230 reference statements)

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“…The absence of one or more pro‐viral factors results in incompatibility in a host plant (Lellis et al , ). Viral proteins must be translated by the host translational machinery before replication can occur (Ahlquist, ; Machado et al , ; Miller et al , ). This feature makes viral RNA translation a critical determinant of the outcome in plant–virus interactions.…”

Section: Compatibility and Susceptibility In Plant–virus Interactionsmentioning

confidence: 99%

Host factors against plant viruses

García-Ruíz

2019

Molecular Plant Pathology

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Plant virus genome replication and movement is dependent on host resources and factors. However, plants respond to virus infection through several mechanisms, such as autophagy, ubiquitination, mRNA decay and gene silencing, that target viral components. Viral factors work in synchrony with pro-viral host factors during the infection cycle and are targeted by antiviral responses. Accordingly, establishment of virus infection is genetically determined by the availability of the pro-viral factors necessary for genome replication and movement, and by the balance between plant defence and viral suppression of defence responses. Sequential requirement of pro-viral factors and the antagonistic activity of antiviral factors suggest a two-step model to explain plant-virus interactions. At each step of the infection process, host factors with antiviral activity have been identified. Here we review our current understanding of host factors with antiviral activity against plant viruses.

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Section: Compatibility and Susceptibility In Plant–virus Interactionsmentioning

confidence: 99%

Host factors against plant viruses

García-Ruíz

2019

Molecular Plant Pathology

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“…Although NIK1 is structurally related to SERKs and is also implicated in plant immunity, the mechanism by which NIK1 propagates an antiviral signal, and the resulting immune responses are entirely different from the BAK1/SERK3‐dependent PTI response against pathogens (Machado et al , ). The mechanism of NIK1‐mediated defence is underscored by repression of translational machinery genes and suppression of global translation, as a new paradigm for plant antiviral immunity (Machado et al , ; Zorzatto et al , ).…”

Section: Introductionmentioning

confidence: 99%

Virus perception at the cell surface: revisiting the roles of receptor‐like kinases as viral pattern recognition receptors

Teixeira

Ferreira

Raimundo

et al. 2019

Molecular Plant Pathology

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Summary Activation of antiviral innate immune responses depends on the recognition of viral components or viral effectors by host receptors. This virus recognition system can activate two layers of host defence, pathogen‐associated molecular pattern (PAMP)‐triggered immunity (PTI) and effector‐triggered immunity (ETI). While ETI has long been recognized as an efficient plant defence against viruses, the concept of antiviral PTI has only recently been integrated into virus–host interaction models, such as the RNA silencing‐based defences that are triggered by viral dsRNA PAMPs produced during infection. Emerging evidence in the literature has included the classical PTI in the antiviral innate immune arsenal of plant cells. Therefore, our understanding of PAMPs has expanded to include not only classical PAMPS, such as bacterial flagellin or fungal chitin, but also virus‐derived nucleic acids that may also activate PAMP recognition receptors like the well‐documented phenomenon observed for mammalian viruses. In this review, we discuss the notion that plant viruses can activate classical PTI, leading to both unique antiviral responses and conserved antipathogen responses. We also present evidence that virus‐derived nucleic acid PAMPs may elicit the NUCLEAR SHUTTLE PROTEIN‐INTERACTING KINASE 1 (NIK1)‐mediated antiviral signalling pathway that transduces an antiviral signal to suppress global host translation.

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“…Hence, our data provides further insights into translation regulation during plant immunity, showing that the RNA-binding activity of multiple components of the translation machinery, including ribosomal proteins, is altered in response to flg22. A similar global translational slowdown has been suggested to play important roles as an antiviral strategy 37 and to occur during responses to abiotic stresses such as hypoxia 38 , heat 39 or drought 40 . We hypothesise that this phenomenon may play a role in or be a consequence of the described switch from translation of growthrelated mRNAs to those involved in rapid adaptive responses 36 .…”

Section: Flg22 Treatment Inhibits Rbps Involved In Editing and Proteimentioning

confidence: 86%

Proteome-wide Profiling of RNA-Binding Protein Responses to flg22 Reveals Novel Components of Plant Immunity

Bach‐Pages

Chen

Sanguankiattichai

et al. 2020

Preprint

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RNA-binding proteins (RBPs) play critical roles in post-transcriptional gene regulation and are known to contribute to plant immunity. To understand the responses of cellular RBPs to an immune elicitor, we applied RNA interactome capture to Arabidopsis leaves treated with flg22. Strikingly, flg22 induced a pervasive remodelling of the cellular RBPome affecting 186 proteins. Flg22-responsive RBPs included classical RBPs involved in RNA metabolism as well as non-canonical RBPs. RBP responders detected after 2h of treatment are enriched in putative sites for post-translational modifications, which may play a regulatory role. By contrast, changes in RBP abundance becomes increasingly important for the RBPome responses to flg22 after 12h. Plant resistance to Pseudomonas syringae is strongly altered in mutant lines lacking individual flg22-responsive RBPs, supporting the importance of RBP dynamics in plant immunity. This study provides a comprehensive and systematic census of flg22 responsive plant RBPs, discovering novel components of plant immunity.

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Translational control in plant antiviral immunity

Cited by 33 publications

References 122 publications

Host factors against plant viruses

Host factors against plant viruses

Virus perception at the cell surface: revisiting the roles of receptor‐like kinases as viral pattern recognition receptors

Proteome-wide Profiling of RNA-Binding Protein Responses to flg22 Reveals Novel Components of Plant Immunity

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