Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis

Patel, Prabhudas S; Thennavan, Aatish; Sen, Subhalakshmi; Chandrashekar, Chetana; Radhakrishnan, Raghu

doi:10.2334/josnusd.57.169

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…While oxidative stress is indeed associated with OSMF, tissue inflammation is crucial for the induction of tissue fibrosis. The involvement of prostanoids and other inflammatory mediators [90,91] as well as immune cells (recently reviewed in [92]) is central to OSMF pathogenesis but was not in the scope of our review.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

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Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. To assess the scope for mechanism-based approaches to prevent or reverse OSMF, we systematically evaluated the existing literature and investigated the role of oxidative stress in the pathogenesis and chemoprevention of OSMF. A search for relevant articles on PubMed and Scopus was undertaken using pre-defined inclusion and exclusion criteria. A total of 78 articles were selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The articles eligible for assessment investigated both OSMF and/or oxidative stress biomarkers or specific antioxidants. Both in vitro and human studies consistently demonstrated variations in oxidative stress biomarker levels in OSMF and revealed an increase in oxidative stress, paralleling the development of the disease. Furthermore, the use of antioxidant supplements was overall associated with an improvement in clinical outcomes. Having identified the significance of oxidative stress in OSMF and the therapeutic potential of antioxidant supplements, this scoping review highlights the need for further well-designed studies in the development of mechanism-based interventions for managing OSMF.

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Section: Strengths and Limitationsmentioning

confidence: 99%

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

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“…The role of COX-2 in carcinogenesis is also suggested by studies which have revealed a lower risk of developing a malignant tumour in those patients receiving COX-2 inhibitors [ 102 ]. Patel et al pointed out that COX-2 overexpression could be correlated with the risk of recurrence of OSCC [ 103 ].…”

Section: Markers Of Inflammation In Osccmentioning

confidence: 99%

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Tampa

Mitran

et al. 2018

Journal of Immunology Research

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Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.

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Significance of p53 overexpression in the prediction of the malignant transformation risk of oral potentially malignant disorders: A systematic review and meta-analysis

2022

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Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis

Cited by 4 publications

References 17 publications

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Significance of p53 overexpression in the prediction of the malignant transformation risk of oral potentially malignant disorders: A systematic review and meta-analysis

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