Translational Applications of Artificial Intelligence and Machine Learning for Diagnostic Pathology in Lymphoid Neoplasms: A Comprehensive and Evolutive Analysis

Abstract

Genomic analysis and digitalization of medical records have led to a big data scenario within hematopathology. Artificial intelligence and machine learning tools are increasingly used to integrate clinical, histopathological, and genomic data in lymphoid neoplasms. In this study, we identified global trends, cognitive, and social framework of this field from 1990 to 2020. Metadata were obtained from the Clarivate Analytics Web of Science database in January 2021. A total of 525 documents were assessed by document type, research areas, source titles, organizations, and countries. SciMAT and VOSviewer package were used to perform scientific mapping analysis. Geographical distribution showed the USA and People’s Republic of China as the most productive countries, reporting up to 190 (36.19%) of all documents. A third-degree polynomic equation predicts that future global production in this area will be three-fold the current number, near 2031. Thematically, current research is focused on the integration of digital image analysis and genomic sequencing in Non-Hodgkin lymphomas, prediction of chemotherapy response and validation of new prognostic models. These findings can serve pathology departments to depict future clinical and research avenues, but also, public institutions and administrations to promote synergies and optimize funding allocation.

Application of machine learning in the management of lymphoma: Current practice and future prospects

“…Pathology is an essential examination method for the diagnosis of malignant lymphoma. 13 Automatic image preprocessing reduces the overall workload of hematologists and pathologists. The initial attempt is to start with image preprocessing, then object recognition, feature extraction, and finally classify different cells.…”

Digital Pathology: New Initiative in Pathology

“…AI and machine learning tools are increasingly being used to integrate clinical, histopathological, and genomic data [ 10 ]. Moran-Sanchez et al [ 11 ] obtained metadata in this field from the Clarivate Analytics Web of Science database from 1990 to 2020. A total of 525 documents were assessed by document type, field of study, source title, organization, and country.…”