Translational and rotational diffusion of flexible PEG and rigid dendrimer probes in sodium caseinate dispersions and acid gels

Salami, S.; Rondeau-Mouro, Corinne; Barhoum, M.; Duynhoven, John van; Mariette, François

doi:10.1002/bip.22492

Cited by 11 publications

(5 citation statements)

References 34 publications

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“…Due to the interdependence between diffusion and the mesoscopic gel structure, diffusion studies may also be used to explore the dynamics and to extract information on the network morphology [5][6][7][8][9]. Experimental techniques for studying the diffusion of colloids and macromolecules in gels include dynamic light scattering [10], diffusive wave spectroscopy [9], and NMR [8,11]. The tracking of fluorescently labeled particles has shown the complex diffusion processes both in gels and in different biological matrices [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Tracer diffusion in a polymer gel: simulations of static and dynamic 3D networks using spherical boundary conditions

Kamerlin

Elvingson

2016

J. Phys.: Condens. Matter

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We have investigated an alternative to the standard periodic boundary conditions for simulating the diffusion of tracer particles in a polymer gel by performing Brownian dynamics simulations using spherical boundary conditions. The gel network is constructed by randomly distributing tetravalent cross-linking nodes and connecting nearest pairs. The final gel structure is characterised by the radial distribution functions, chain lengths and end-to-end distances, and the pore size distribution. We have looked at the diffusion of tracer particles with a wide range of sizes, diffusing in both static and dynamic networks of two different volume fractions. It is quantitatively shown that the dynamical effect of the network becomes more important in facilitating the diffusional transport for larger particle sizes, and that one obtains a finite diffusion also for particle sizes well above the maximum in the pore size distribution.

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Section: Introductionmentioning

confidence: 99%

Tracer diffusion in a polymer gel: simulations of static and dynamic 3D networks using spherical boundary conditions

Kamerlin

Elvingson

2016

J. Phys.: Condens. Matter

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“…Measurements of self-diffusion of nanoparticles in biopolymer gels can be used to extract information on the physical properties of the constituent polymer network. Where the mobility of larger colloidal particles reflects the elastic properties of the gel (microrheology), diffusion of smaller particles gives information about the details of gel submicron structure (nanoprobe diffusometry). − Nanoprobe diffusometry has been used in both polysaccharide − and protein − gels or phase-separated mixtures thereof …”

Section: Introductionmentioning

confidence: 99%

Complex Coacervate Core Micelles with Spectroscopic Labels for Diffusometric Probing of Biopolymer Networks

et al. 2015

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We present the design, preparation, and characterization of two types of complex coacervate core micelles (C3Ms) with cross-linked cores and spectroscopic labels and demonstrate their use as diffusional probes to investigate the microstructure of percolating biopolymer networks. The first type consists of poly(allylamine hydrochloride) (PAH) and poly(ethylene oxide)-poly(methacrylic acid) (PEO-b-PMAA), labeled with ATTO 488 fluorescent dyes. We show that the size of these probes can be tuned by choosing the length of the PEO-PMAA chains. ATTO 488-labeled PEO113-PMAA15 micelles are very bright with 18 dye molecules incorporated into their cores. The second type is a (19)F-labeled micelle, for which we used PAH and a (19)F-labeled diblock copolymer tailor-made from poly(ethylene oxide)-poly(acrylic acid) (mPEO79-b-PAA14). These micelles contain approximately 4 wt % of (19)F and can be detected by (19)F NMR. The (19)F labels are placed at the end of a small spacer to allow for the necessary rotational mobility. We used these ATTO- and (19)F-labeled micelles to probe the microstructures of a transient gel (xanthan gum) and a cross-linked, heterogeneous gel (κ-carrageenan). For the transient gel, sensitive optical diffusometry methods, including fluorescence correlation spectroscopy, fluorescence recovery after photobleaching, and super-resolution single nanoparticle tracking, allowed us to measure the diffusion coefficient in networks with increasing density. From these measurements, we determined the diameters of the constituent xanthan fibers. In the heterogeneous κ-carrageenan gels, bimodal nanoparticle diffusion was observed, which is a signpost of microstructural heterogeneity of the network.

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“…Salami et al . () reported that the D of PEG in sodium caseinate acid gels determined by PFG‐NMR were greatly influenced by the size of the probe and the gel matrix topology. Remarkably, diffusion in such gels appears to be almost fully controlled by the free volume that is accessible to the tracers (Balakrishnan et al ., ).…”

Section: Resultsmentioning

confidence: 99%

Microstructure and model solute transport properties of transglutaminase‐induced soya protein gels: effect of enzyme dosage, protein composition and solute size

Hua

Kong

et al. 2017

Int J of Food Sci Tech

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Summary The diffusion of poly(ethylene glycol) (PEG) in transglutaminase (TGase) cross‐linked soya protein gels as affected by enzyme dosage and protein composition was investigated. PEG with different molecular weights (Mw) varying from 6000 to 400 000 g mol−1 was selected. Results of this study revealed that the time‐related release of PEG from gel slices was found to be controlled by Fickian diffusion process. For PEG with Mw 6000 g mol−1, the diffusion coefficients (D) were independent on the enzyme dosage and protein composition. However, for PEG with Mw ≥ 20 000 g mol−1, there were strong dependences of diffusion on the solute size and on the gel network microstructure revealed by scanning electron microscopy (SEM), where more density gel network with smaller pores resulted in lower D of PEG. Lower D values of PEG with Mw ≥ 20 000 g mol−1 were obtained in gels induced by 2 U g−1 TGase, and the D values increased with increasing 11S ratio in gels. Moreover, data also showed that the diffusion of PEG with larger size was more sensitive to the variation of gel network.

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Translational and rotational diffusion of flexible PEG and rigid dendrimer probes in sodium caseinate dispersions and acid gels

Cited by 11 publications

References 34 publications

Tracer diffusion in a polymer gel: simulations of static and dynamic 3D networks using spherical boundary conditions

Tracer diffusion in a polymer gel: simulations of static and dynamic 3D networks using spherical boundary conditions

Complex Coacervate Core Micelles with Spectroscopic Labels for Diffusometric Probing of Biopolymer Networks

Microstructure and model solute transport properties of transglutaminase‐induced soya protein gels: effect of enzyme dosage, protein composition and solute size

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