“…8,104,105 Factors that originate and influence the progression of these pathologies can be environmental, genetic (mother, fetus, father, or even all 3), or due to an interaction between the mother and the placenta. Furthermore, PE demonstrates a wide range of patient symptoms, placental histopathology, 8,9,[106][107][108] and molecular heterogeneity. 9,82,108 As such, a significant criticism of the majority of published microarray studies is the treatment of PE as a single pathology, which is counter to this assessment of multifactorial disease.…”