Translation and validation of Sinhala version of modified EORTC QLQ-OH15 in oral cancer patients who receive radiotherapy with or without chemotherapy in Sri Lanka

Kosgallana, Shamini; Jayasekara, Prasanna; Abeysinghe, Prasad; Hjermstad, Marianne Jensen; Lalloo, Ratilal

doi:10.1186/s12903-022-02392-y

Cited by 3 publications

(4 citation statements)

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“…This was the first prospective study carried out among the oral cancer patients who receive RT alone or with chemotherapy to assess their OHRQOL and the changes of OHRQOL within three months post RT in Sri Lanka. The OHRQOL was assessed by using modified EORTC QLQ-OH15 questionnaire which was validated for the oral cancer patients who received RT alone or with chemotherapy in Sri Lanka [ 23 ]. The OHRQOL in oral cancer patients became extremely poor during the last week of RT compared to baseline due to RT alone or with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

et al. 2023

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Background Oral cancer is the number one cancer among males in Sri Lanka. Radiotherapy is a common treatment modality for oral cancer, but this can affect oral health related quality of life (OHRQOL). This study assessed the OHRQOL and its changes from baseline to the last week of radiotherapy and three months post radiotherapy among oral cancer patients who received this treatment alone or with chemotherapy. Methods A prospective longitudinal study was conducted among 90 oral cancer patients awaiting for radiotherapy alone or with chemotherapy. The modified Sinhala version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Oral Health Module (EORTC QLQ-OH15) was used to gather data related to OHRQOL before radiotherapy. Socio-demographic and clinical data were also recorded. The same cohort of patients were followed up and assessed their OHRQOL during the last week of radiotherapy and three months post radiotherapy. The Modified EORTC QLQ-OH15 assesses the OHRQOL under three domains namely ‘Eating problem’, ‘Gum and speech problem’ and ‘Soreness’, and one item named as ‘Teeth’. Results The majority of the sample (88%) was males. The anterior two-thirds of the tongue (40%) and buccal mucosa (22%) were the most common sites. The median scores of ‘Eating problem’ domain at baseline, last week of radiotherapy and three months post radiotherapy were 20 (IQR = 6.7–33.3), 100 (IQR = 86.9–100.0) and 66.7 (IQR = 46.7–93.3) respectively. ‘Gum and speech problem’ was higher during last week of radiotherapy (median, 50.0, IQR, 25.0-58.3) than three months post radiotherapy (median, 8.3, IQR, 0.0-33.3). The changes of OHRQOL between the time frames were statistically significant (p < 0.05). Baseline OHRQOL in relation to ‘Gum and speech problem’ domain and ‘Teeth’ item was identified as an influential factor for OHRQOL during last week of radiotherapy. Conclusion The OHRQOL of oral cancer patients who received radiotherapy alone or with chemotherapy had deteriorated from the baseline level to the last week of radiotherapy but then improved at three months post radiotherapy. The OHRQOL however did not return to the baseline level three months post radiotherapy. OHRQOL during the last week of radiotherapy was influenced by the OHRQOL at baseline, civil status and sites of metastasis.

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Section: Discussionmentioning

confidence: 99%

“…In addition, there are two variables to assess the patients’ satisfaction on information they gained during treatment and two variables to assess OHRQOL among denture wearers. A high score represents a high level of symptoms and low level of OHRQOL [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

et al. 2023

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“…Surgery, radiotherapy and chemotherapy are the main modalities of treatment however, as noted above, there is a bias to primary surgery 56 . Oral cancer patients with advanced stages of the disease or who have close surgical margins are recommended for postoperative external beam radiotherapy 59 . Best practice is to initiate radiotherapy within 6 weeks of surgery, but this is frequently significantly stretched due to the demand on radiotherapy and limitation of radiotherapy facilities and patient related factors such as delayed wound healing 60 …”

Section: Differences Between Districts In the Distribution Of Oral Ca...mentioning

confidence: 99%

An overview of the burden of oral cancer in Sri Lanka and its inequalities in the face of contemporary economic and social malaise

Perera

Amarasinghe

Jayasinghe

et al. 2023

Comm Dent Oral Epid

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Objectives: Over the past several decades, oral cancer has been the most common malignancy among Sri Lankan males and the top 10 cancer among females, disproportionately affecting low socio-economic groups. Sri Lanka is a lower-middle-income developing country (LMIC), currently striking through an economic crisis, and social and political unrest. Occurring at an accessible body site and predominantly attributed to potentially modifiable health-related behaviours, oral cancer should be preventable and controllable. Unfortunately, broader contextual factors that are socio-cultural, environmental, economic, and political and mediated through social determinants of people's lives consistently hinder progress. Many LMICs with a high burden of oral cancer are now gripped by economic crises, consequent social and political unrest, all compounded by reduced public health investments. The aim of this review is to provide a critical commentary on key aspects of oral cancer epidemiology including inequalities, using Sri Lanka as a case study. Methods:The review synthesizes evidence from multiple data sources, such as published studies, web-based national cancer incidence data, national surveys on smokeless tobacco (ST) and areca nut use, smoking and alcohol consumption, poverty headcount ratios, economic growth, and Gross Domestic Product (GDP) health expenditure. National trends in the oral cancer, ST use, smoking and alcohol consumption in Sri Lanka are identified alongside inequalities.Results: Using these evidence sources, we discuss 'where are we now?', together with the availability, accessibility and affordability of oral cancer treatment services, oral cancer prevention and control programmes, tobacco and alcohol control policies, and finally, outline macroeconomic perspectives of Sri Lanka.Conclusions: Finally, we speculate, 'where to next?' Our overarching goal of this review is to initiate a critical discourse on bridging the gaps and crossing the divides to tackle oral cancer inequalities in LMIC such as Sri Lanka.

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“…Dysphagia, psychiatric disorders and trismus seriously decrease QoL [ 4 , 5 ]. However, speech is one of the most distressing problems for patients [ 6 – 8 ]. In previous studies, researchers confirmed that chemoradiotherapy and surgery affected patients’ speech intelligibility [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Speech disorders in patients with Tongue squamous cell carcinoma: A longitudinal observational study based on a questionnaire and acoustic analysis

et al. 2023

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Background Speech disorders are common dysfunctions in patients with tongue squamous cell carcinoma (TSCC) that can diminish their quality of life. There are few studies with multidimensional and longitudinal assessments of speech function in TSCC patients. Methods This longitudinal observational study was conducted at the Hospital of Stomatology, Sun Yat-sen University, China, from January 2018 to March 2021. A cohort of 92 patients (53 males, age range: 24–77 years) diagnosed with TSCC participated in this study. Speech function was assessed from preoperatively to one year postoperatively using the Speech Handicap Index questionnaire and acoustic parameters. The risk factors for postoperative speech disorder were analyzed by a linear mixed-effects model. A t test or Mann‒Whitney U test was applied to analyze the differences in acoustic parameters under the influence of risk factors to determine the pathophysiological mechanisms of speech disorders in patients with TSCC. Results The incidence of preoperative speech disorders was 58.7%, which increased up to 91.4% after surgery. Higher T stage (P＜0.001) and larger range of tongue resection (P = 0.002) were risk factors for postoperative speech disorders. Among the acoustic parameters, F2/i/decreased remarkably with higher T stage (P = 0.021) and larger range of tongue resection (P = 0.009), indicating restricted tongue movement in the anterior-posterior direction. The acoustic parameters analysis during the follow-up period showed that F1 and F2 were not significantly different of the patients with subtotal or total glossectomy over time. Conclusions Speech disorders in TSCC patients is common and persistent. Less residual tongue volume led to worse speech-related QoL, indicating that surgically restoring the length of the tongue and strengthening tongue extension postoperatively may be important.

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Translation and validation of Sinhala version of modified EORTC QLQ-OH15 in oral cancer patients who receive radiotherapy with or without chemotherapy in Sri Lanka

Cited by 3 publications

References 20 publications

Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

Oral health related quality of life of oral cancer patients treated with radiotherapy alone or with chemotherapy in a tertiary referral centre in Sri Lanka

An overview of the burden of oral cancer in Sri Lanka and its inequalities in the face of contemporary economic and social malaise

Speech disorders in patients with Tongue squamous cell carcinoma: A longitudinal observational study based on a questionnaire and acoustic analysis

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