Translation and Validation of Kidney Disease and Quality of Life (Kdqol-Sftm 1.2) Instrument to Measure Health Related Quality of Life Of Indian Patients with Kidney Disease

Abstract

Objectives: Objective of the present study was to translate and validate the Kidney Disease Quality of Life-Short form 1.2 (KDQOL-SF TM 1.2) questionnaire in Hindi language for use in Indian Hindi speaking patients with kidney stone. MethOds: Forward and backward translations were performed. Intermediate version of Hindi questionnaire was developed and was used for pilot study (n= 20). Modified final version after pilot study was used for validation study. Results: Questionnaire was administered to patients (n= 99) with kidney stone twice with an interval of four weeks. Cronbach alpha for total score was 0.71. For individual domains i.e. for the domain symptoms and kidney disease alpha value of 0.99 was gained, for the domain burden of kidney disease it was 0.79, for the domain effect of kidney disease on daily life it was 0.82, for the domain pain it was 0.99, for the domain physical functioning it was 0.91 and for the domain sexual function it was 0.99. No significant (p< 0.05) difference was observed in total score in test-retest analysis. cOnclusiOns: Translated Hindi Version of KDQOL-SF TM 1.2 showed good internal consistancy, test-retest reliability and linguistic validity. an outcome measure in interventional studies. Psychological distress is a subset of HRQoL that specifically evaluates the impact on mental health. In addition, social support and patients' perception of illness have been shown to predict all-cause mortality in ESRD patients. However, local data comparing PRO and social support in hemodialysis (HD) vs. peritoneal dialysis (PD) patients are lacking. Hence, the objective of this cross-sectional, observational study was to evaluate and compare patient-reported and laboratory outcomes in our multi-ethnic HD and PD patients. MethOds: Eligible chronic dialysis patients from National University Hospital were recruited. PRO measures include Kidney Disease Quality of Life-Short Form, EuroQoL-5 Dimensions and Kessler Psychological Distress Scale. Social support was assessed using Family Functioning Measure. Relevant sociodemographic information and medication list/laboratory parameters were captured using a pretested health services utilization questionnaire, and clinic notes/electronic medical records respectively. All data were analysed and compared between HD and PD patients using Stata version 10. Results: A total of 113 patients were recruited (HD: n= 81, PD: n= 32). There were no significant differences in HRQoL, social support, level of distress and most laboratory parameters between HD and PD patients. However, HD patients had significantly higher serum albumin levels (38.2±3.6 g/L vs. 32.5±4.5 g/L, p< 0.001) while PD patients had significantly higher serum corrected calcium levels (2.41±0.2 mmol/L vs. 2.27±0.2 mmol/L, p= 0.004) and number of medications (10.1±3.1 vs. 8.8±2.9, p= 0.039). cOnclusiOns: Barring cost and patient-specific factors, HD and PD are likely equivalent therapeutic options for ESRD patients in Singapore. However, the findings need to be confirmed in a larger study.

Assessment of health-related quality of life and its determinants in patients with chronic kidney disease

“…[41214162223] We found that lower hemoglobin levels were associated with poor KDCS and PCS whereas older age was associated with poor PCS. The presence of comorbidities had no impact on HRQoL.…”

“…[9] Validation studies have been undertaken in Indian languages including Kannada, Marathi, and Hindi. [101112] A study with a translated Tamil version has also been published. [13]…”

“…There is minimal literature on HRQoL in CKD patients from low and middle-income countries, including India. [345678910111213] A few issues unique to the developing world which could potentially affect the HRQoL include age, economic status, literacy level, loss of employment, and gender bias. Apart from the disease and its complications, socioeconomic and cultural environment of the patients also play a major role in determining HRQoL.…”

“…There is only limited data on HRQoL in CKD from Indian subcontinent. [456910111213] Most of the Indian studies are limited to patients having advanced CKD or end stage renal disease (ESRD). Considering the social and cultural diversity in India, there can be significant differences in HRQoL and its determinants across the country.…”

Psychological status and intervention strategy of maintenance hemodialysis patients in COVID-19 epidemic

“…Kidney Disease and Quality of Life-Short Form (KDQOL-SF) can be de ned as a kidney patient's usual or expected physical, emotional well-being, or social experience that consists a 36-item short form health survey (SF36) and kidney disease target areas (KDTAs). It is a comprehensive assessment of general health status and kidneydisease-related clinical characteristics [15].KDQOL-SF is an overall assessment of QOL in MHD patients.…”