Translating Research Into Clinical Practice

Fan, Qiwei; Jia, Jie

doi:10.1161/strokeaha.119.027345

Cited by 10 publications

(2 citation statements)

References 75 publications

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“…Low or unhealthy CRF is an independent and strong predictor of cardiovascular disease and adult all-cause mortality [6] . The CRF of the stroke population, with an average level of 15.78 ml/kg/min [7] , was about 53% of that of the age-matched healthy population [8] . This level predicts an inability to maintain daily activities and may be associated with a range of adverse outcomes, including frailty, reduced physical performance, an increased risk of cardiovascular events, and an increased rate of recurrent stroke [9] .…”

Section: Introductionmentioning

confidence: 87%

A resting-state fMRI cross-sectional study of CRF decline after stroke

Qu,

Zhang,

Wang

et al. 2023

Preprint

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Objective To analyze the changes of neural activity intensity and brain functional network in brain functional areas after the decrease of CRF in stroke patients by using resting-state fMRI, so as to find the possible brain areas of CRF in stroke patients. Methods Twenty-two stroke patients were recruited according to the inclusion criteria of the study, and 15 age -, gender - and BMI - matched healthy control were recruited. Both stroke patients and healthy control underwent behavioral assessment and resting-state fMRI scan. Rehabilitation assessments included peak oxygen consumption (VO2peak), peak work-rate, 10-meter walk test (10mWT), five times sit-to-stand test (FTSST), and 6-minute walk test (6MWT). The resting-state fMRI data of the two groups were collected, and the correlation between the changes of amplitude of low frequency fluctuations (ALFF) and CRF was analyzed to find out the brain regions related to CRF and local neural activity in stroke patients. On the basis of ALFF analysis, the brain network analysis was carried out, and the CRF related brain regions of stroke patients were selected as seed points. Through functional connectivity analysis, the CRF and brain network related brain regions of stroke patients were found out. Results VO2peak, Work-rate peak, 10mWT and 6MWD in stroke patients were significantly lower than those in healthy control (P<0.001). FTSST in stroke patients was significantly higher than that in healthy control (P<0.001). ALFF analysis showed that the brain regions related to CRF in stroke patients were the ipsilesional superior temporal gyrus (r=0.5826, P=0.0002), the middle frontal gyrus (r=0.6340, P<0.0001) and the precentral gyrus (r=0.5895, P=0.0001). Functional connectivity analysis showed that the functional connectivity of brain regions related to CRF in stroke patients was from ipsilesional M1 to ipsilesional precentral gyrus and contralesional postcentral gyrus, and the correlation coefficients were (r=0.5263, P=0.0008) and (r=0.4595, P=0.0042), respectively. The correlation coefficients of ipsilesional middle frontal gyrus to contralesional middle frontal gyrus, angular gyrus and ipsilesional superior frontal gyrus were (r=0.5509, P=0.0004), (r=0.5192, P=0.001) and (r=-0.666, P<0.001), respectively. Conclusion The CRF, peak work-rate, 10-meter walk test and 6-minute walk distance of the stroke subjects were lower than those of the healthy control, while the five times sit-to-stand test was the opposite, which verified the fact that CRF would decrease after stroke. The resting-state fMRI index ALFF analysis showed that the relevant brain regions of CRF and local neural activity in stroke patients were the ipsilesional superior temporal gyrus, middle frontal gyrus and precentral gyrus. The FC showed that the relevant brain regions of CRF and brain network in stroke patients were ipsilesional M1 to ipsilesional precentral gyrus and contralesional postcentral gyrus, ipsilesional middle frontal gyrus to contralesional middle frontal gyrus, angular gyrus and ipsilesional superior frontal gyrus.

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Section: Introductionmentioning

confidence: 87%

A resting-state fMRI cross-sectional study of CRF decline after stroke

Qu,

Zhang,

Wang

et al. 2023

Preprint

Self Cite

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“…A cross-sectional study showed that improvements in post-stroke sarcopenia were related to a higher discharge rate and better functional independence rating scale (FIM) scores [32][33], suggesting that sarcopenia treatment in stroke patients formed the basis of the improvements in performing daily activities. On the other hand, the impact of stroke on the cardiovascular, respiratory, and neuromuscular systems may affect cardiopulmonary health after stroke, and the cardiopulmonary function of stroke patients can remain reduced for several years [34]; inspiratory muscle training can effectively improve respiratory function, cardiopulmonary endurance, and reduce the incidence of pneumonia incidence after stroke [35][36][37]. Respiratory muscle training involves long and repeated resistance training of the respiratory muscles, which is conducive to improving respiratory endurance and allowing patients to make more effective use of the respiratory muscles in daily life [38].…”

Section: Inspiratory Muscle Training and Mbi And Mrsmentioning

confidence: 99%

The value of inspiratory muscle training on post-stroke sarcopenia and its effect on rehabilitation outcomes: A randomized controlled trial

Zhao

Shao

Wang

et al. 2023

Preprint

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Purpose: The study aimed to verify the value of inspiratory muscle training (IMT) in the prevention of post-stroke sarcopenia, and to analyze the effects of IMT on the rehabilitation prognosis, including daily living activities, social regression, balance, and pneumonia, of stroke patients. Methods: A total of 367 patients with a first stroke event were randomly allocated to an experimental group (n =164) and a control group (n =165). Both groups received conventional neurological rehabilitation treatment, and the experimental group also received IMT. After eight weeks of treatment, the incidence of post-stroke sarcopenia and pneumonia were analyzed and compared. The maximum inspiratory pressure (MIP) was assessed using a respiratory resistance trainer, and the Modified Barthel Index (MBI) was used to assess activities of daily living (ADL). The ability to return to society was assessed using the modified Rankin Scale (mRS), the trunk impact scale (TIS) was used to evaluate trunk balance in both groups before and after treatment, and the differences in MIP, MBI, mRs, and TIS between the two groups were analyzed. Results: There were no significant differences in the baseline demographics between the two groups. After eight weeks of treatment, the incidence of post-stroke sarcopenia (P =0.004) and pneumonia (P =0.017) in the experimental group was lower than that in the control group. The trial group performed better than control group in MBI (P =0.02, effect size d =0.3), TIS (P < 0.001, effect size d =0.52), MIP (P < 0.001, effect size d =0.4) and mRS (P =0.001, effect size d =0.3) scores after intervention. Conclusion: Early inspiratory muscle training can effectively reduce the incidence of post-stroke sarcopenia and pneumonia and improve the rehabilitation prognosis of patients after stroke. (clinicaltrials.ChiCTR2200057067).

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