Translating red cell “omics” into new perspectives in transfusion medicine: mining the gems in the data mountains

Spitalnik, Steven L.; Devine, Dana V.

doi:10.1111/trf.15066

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…18 To support this, specific variants in ankyrin and spectrin genes have been found related to osmotic hemolysis in vitro. 19 On the opposite side, storage hemolysis, the gold quality standard of hypothermic preservation of RBCs, is a multivariable phenotype, related to a wide array of biochemical, metabolic, physiological, lifestyle, and hormone parameters, 7,20 including osmotic hemolysis. 5 We have previously estimated that osmotic hemolysis contributes by 9%-10% to the total free hemoglobin content of the blood unit, 15 a rather significant proportion considering the multiparametric nature of storage hemolysis.…”

Section: Discussionmentioning

confidence: 99%

Osmotic hemolysis is a donor‐specific feature of red blood cells under various storage conditions and genetic backgrounds

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Osmotic hemolysis is a donor‐specific feature of red blood cells under various storage conditions and genetic backgrounds

et al. 2021

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“…The concept of "precision transfusion medicine" was developed to move toward a future where blood donor selection, component processing and storage are optimized for transfusion recipients with the aim of improving blood safety and efficacy. [63][64][65] Knowledge generated from studies of linked datasets has the potential to change the way donors are selected and how components are processed, stored and allocated. By characterizing specific donor, component, and recipient factors, these analyses also provide evidence to guide the design and conduct of future clinical trials.…”

mentioning

confidence: 99%

“…neonates, sickle cell disease). The concept of 'precision transfusion medicine' was developed to move towards a future where blood donor selection, component processing and storage are optimized for transfusion recipients with the aim of improving blood safety and efficacy [63][64][65].…”

mentioning

confidence: 99%

Methodological considerations for linked blood donor‐component‐recipient analyses in transfusion medicine research

Roubinian

Kleinman

Murphy

et al. 2019

ISBT Science Series

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In recent years, there has been a concerted effort to improve our understanding of the quality and effectiveness of transfused blood components. The expanding use of large datasets built from electronic health records allows the investigation of potential benefits or adverse outcomes associated with transfusion therapy. Together with data collected on blood donors and components, these datasets permit an evaluation of associations between donor or blood component factors and transfusion recipient outcomes. Large linked donor-component recipient datasets provide the power to study exposures relevant to transfusion efficacy and safety, many of which would not otherwise be amenable to study for practical or sample size reasons. Analyses of these large blood banking-transfusion medicine datasets allow for characterization of the populations under study and provide an evidence base for future clinical studies. Knowledge generated from linked analyses have the potential to change the way donors are selected and how components are processed, stored and allocated. However, unrecognized confounding and biased statistical methods continue to be limitations in the study of transfusion exposures and patient outcomes. Results of observational studies of blood donor demographics, storage age, and transfusion practice have been conflicting. This review will summarize statistical and methodological challenges in the analysis of linked blood donor, component, and transfusion recipient outcomes.In the past three decades, there has been a concerted effort to improve our understanding of the quality, safety, and effectiveness of transfused blood components. [1][2][3] Significant research has focused on blood donors, on component manufacturing and storage, and optimal

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Purported Adverse Effects of ‘Old Blood’

Triulzi

2022

Practical Transfusion Medicine

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Translating red cell “omics” into new perspectives in transfusion medicine: mining the gems in the data mountains

Abstract: http://onlinelibrary.wiley.com/doi/10.1111/trf.14971/full

Cited by 4 publications

References 20 publications

Osmotic hemolysis is a donor‐specific feature of red blood cells under various storage conditions and genetic backgrounds

Osmotic hemolysis is a donor‐specific feature of red blood cells under various storage conditions and genetic backgrounds

Methodological considerations for linked blood donor‐component‐recipient analyses in transfusion medicine research

Purported Adverse Effects of ‘Old Blood’

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