Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury
Ilaria Lisi,
Federico Moro,
Edoardo Mazzone
et al.
Abstract:Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing potential new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%, perhaps due, in part, to distinct timescales of pathophysiological processes in rodents versus humans that impedes translational advancements. Incorporating clinically relevant biomarkers in precl… Show more
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