Translating Colonic Sensory Afferent Peripheral Mechanosensitivity into the Spinal Cord Dorsal Horn

Harrington, Andrea M.

doi:10.1007/978-3-031-25702-5_13

Cited by 1 publication

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“…As for the spinal innervation, retrograde tracing studies, in both rats and mice, illustrate that the spinal afferent innervation of the distal colon through to the rectum projects into discreet regions of the dorsal horn within the thoracolumbar (TL; T10–L1) and lumbosacral (LS; L5–S2) spinal cord (Ge et al., 2019; Harrington et al., 2019). In contrast to the vagal pathway, numerous studies have explored various aspects of the dorsal horn circuits processing colorectal afferent input (Harrington, 2023). Collectively, these studies indicate that the dorsal horn circuits facilitating colorectal nociceptive transmission into the brain differ between the TL and LS spinal cord (Harrington et al., 2019; Katter et al., 1996; Murphy et al., 2009; Ness et al., 1987, 1988, 1989; Palecek & Willis, 2003; Palecek et al., 2003; Traub et al., 1993, 2002; Wang et al., 2005).…”

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confidence: 99%

Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex

Wang,

Caraballo,

Rychkov

et al. 2023

J of Comparative Neurology

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The distal colon and rectum (colorectum) are innervated by spinal and vagal afferent pathways. The central circuits into which vagal and spinal afferents relay colorectal nociceptive information remain to be comparatively assessed. To address this, regional colorectal retrograde tracing and colorectal distension (CRD)‐evoked neuronal activation were used to compare the circuits within the dorsal vagal complex (DVC) and dorsal horn (thoracolumbar [TL] and lumbosacral [LS] spinal levels) into which vagal and spinal colorectal afferents project. Vagal afferent projections were observed in the nucleus tractus solitarius (NTS), area postrema (AP), and dorsal motor nucleus of the vagus (DMV), labeled from the rostral colorectum. In the NTS, projections were opposed to catecholamine and pontine parabrachial nuclei (PbN)‐projecting neurons. Spinal afferent projections were labeled from rostral through to caudal aspects of the colorectum. In the dorsal horn, the number of neurons activated by CRD was linked to pressure intensity, unlike in the DVC. In the NTS, 13% ± 0.6% of CRD‐activated neurons projected to the PbN. In the dorsal horn, at the TL spinal level, afferent input was associated with PbN‐projecting neurons in lamina I (LI), with 63% ± 3.15% of CRD‐activated neurons in LI projecting to the PbN. On the other hand, at the LS spinal level, only 18% ± 0.6% of CRD‐activated neurons in LI projected to the PbN. The collective data identify differences in the central neuroanatomy that support the disparate roles of vagal and spinal afferent signaling in the facilitation and modulation of colorectal nociceptive responses.

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