Abstract:Atopic dermatitis affects a substantial number of children, many of whom seek initial treatment from their pediatrician or other primary care provider. Approximately two-thirds of these patients have mild disease and can be adequately managed at the primary care level. However, recent treatment guidelines are written primarily for use by specialists and lack certain elements that would make them more useful to primary care providers. This article evaluates these recent treatment guidelines in terms of evaluati… Show more
“…Although specialists in allergy and dermatology might be able to read through the extensive guidelines and supporting references, primary care clinicians, who take care of the majority of patients with mild-tomoderate AD, need streamlined guidelines that can be incorporated into their busy practices. 8…”
Section: Limitations Of Current Guidelinesmentioning
“…Although specialists in allergy and dermatology might be able to read through the extensive guidelines and supporting references, primary care clinicians, who take care of the majority of patients with mild-tomoderate AD, need streamlined guidelines that can be incorporated into their busy practices. 8…”
Section: Limitations Of Current Guidelinesmentioning
“…For this group, lower-potency TCS (classes 6–7) are generally applied once or twice daily or medium-potency TCS (classes 3–5) once or twice weekly as maintenance therapy [6]. Higher-potency TCS are reserved for the treatment of acute disease flares with pediatric guidelines limiting the use from several days to a few weeks [6, 7]. However, repeated or prolonged use of high-potency TCS is often warranted for those with severe skin disease.…”
Background/Aims: A meta-analysis was performed to determine the likelihood of hypothalamic-pituitary-adrenal (HPA) axis suppression following short-term cutaneous treatment of atopic dermatitis with topical corticosteroids (TCS) in pediatric patients. Methods: All published pediatric clinical trials evaluating TCS use with pre- and post-treatment HPA axis assessment by cosyntropin stimulation testing were included. Results: Of 128 eligible trials, 12 were selected for meta-analysis with a total of 522 participants. There were 20 observed cases of HPA axis suppression (3.8%, 95% CI 2.4–5.8). The percentage of HPA axis suppression with low- (classes 6–7), medium- (classes 3–5) and high-potency (classes 1–2) TCS use was 2% (3 of 148 patients, 95% CI 0.7–5.8), 3.1% (7 of 223 patients, 95% CI 1.5–6.3), and 6.6% (10 of 151 patients, 95% CI 3.6–11.8), respectively. Conclusion: There is a low rate of reversible HPA axis suppression with the use of mid- to low-potency TCS compared to more potent formulations. In pediatric clinical practice, the limited use of mid- to low-potency TCS is rarely associated with clinically significant adrenal insufficiency or adrenal crisis. In the absence of signs and symptoms of adrenal insufficiency, there is little need to test the HPA axis of these patients.
“…Whether prescriptions issued by dermatologists induced fewer adverse events and/or less glucocorticoid phobia than those issued by general practitioners or other physicians remains unknown. Nevertheless, if indeed topical glucocorticoids are prescribed much more frequently by physicians other than dermatologists, all initiatives to improve the use of these treatments in primary care, as has been done for atopic dermatitis, are welcome.…”
About 12% of the French general population is prescribed topical glucocorticoids at least once each year. Most prescriptions are issued by general practitioners, dermatologists being the prescribers in less than one-quarter of cases.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.