[Translated article] Use of an Endobronchial Valve for Management of a Persistent Air-leak in a Child with Necrotizing Pneumonia

The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis

“…At present, the pathological mechanism of ALI induced by SARS CoV-2 is not completely clear. According to literature reports, the mechanism can be summarized as follows: First, IL-1 is considered to be the "culprit" of the lung injury cytokine storm and the key cause of cytokine release syndrome ( Piñeiro Roncal et al, 2021 ; Visca et al, 2021 ).. Moreover, we found that Deh reduced inflammation and oxidative stress to present lung injury in vivo or in vitro.…”

“…COVID-19 infection can exhibit severe pulmonary edema, dyspnea, hypoxemia, and even acute respiratory distress syndrome. A study of standardized autopsy results and clinical data in the medical records of 13 patients who died of COVID-19 showed that secondary alveolar injury caused by focal capillary microthrombosis in the lung was the cause of death ( Piñeiro Roncal et al, 2021 ). At present, the pathological mechanism of ALI induced by SARS CoV-2 is not completely clear.…”