[Translated article] Prognostic Value of Vitamin D Serum Levels in Cutaneous Melanoma

Moro, Ruggero; Sánchez-Silva, Ana; Aguerralde-Martin, Maider; González‐Cuevas, Rubén; Peruilh-Bagolini, Leonardo; Traves, Víctor; Manrique‐Silva, Esperanza; Requena, Celia; Nagore, Eduardo

doi:10.1016/j.ad.2021.11.007

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Studies have demonstrated a link between vitamin D deficiency and an increased risk of developing melanomas (Table 3). Lower plasma vitamin D levels are associated with the development of melanoma and/or reduced survival time in patients with metastatic melanoma [74][75][76][77][78][79][80]. Additionally, studies have also explored the relationship between dietary vitamin D supplements and the incidence of melanoma [11].…”

Section: Vitamin D Deficiency and Melanomamentioning

confidence: 99%

Vitamin D in Melanoma: Potential Role of Cytochrome P450 Enzymes

Ben-Eltriki,

Gayle,

Paras

et al. 2024

Life

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Vitamin D is a promising anticancer agent for the prevention and treatment of several cancers, including melanoma. Low 25-hydroxyvitamin D levels, a routinely used marker for vitamin D, have been suggested as one of the factors in the development and progression of melanoma. The parent vitamin D needs activation by cytochrome P450 (CYP) enzymes to exert its actions via the vitamin D receptor (VDR). This review discusses the role of vitamin D in melanoma and how CYP-mediated metabolism can potentially affect the actions of vitamin D. Through interacting with the retinoid X receptor, VDR signaling leads to anti-inflammatory, antioxidative, and anticancer actions. Calcitriol, the dihydroxylated form of vitamin D3, is the most active and potent ligand of VDR. CYP27A1, CYP27B1, and CYP2R1 are involved in the activation of vitamin D, whereas CYP24A1 and CYP3A4 are responsible for the degradation of the active vitamin D. CYP24A1, the primary catabolic enzyme of calcitriol, is overexpressed in melanoma tissues and cells. Several drug classes and natural health products can modulate vitamin D-related CYP enzymes and eventually cause lower levels of vitamin D and its active metabolites in tissues. Although the role of vitamin D in the development of melanoma is yet to be fully elucidated, it has been proposed that melanoma prevention may be significantly aided by increased vitamin D signaling. Furthermore, selective targeting of the catabolic enzymes responsible for vitamin D degradation could be a plausible strategy in melanoma therapy. Vitamin D signaling can be improved by utilizing dietary supplements or by modulating CYP metabolism. A positive association exists between the intake of vitamin D supplements and improved prognosis for melanoma patients. Further investigation is required to determine the function of vitamin D supplementation and specific enzyme targeting in the prevention of melanoma.

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Section: Vitamin D Deficiency and Melanomamentioning

confidence: 99%

Vitamin D in Melanoma: Potential Role of Cytochrome P450 Enzymes

Ben-Eltriki,

Gayle,

Paras

et al. 2024

Life

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“…In squamous cell carcinoma, vitamin D and topical cholecalciferol supplementation has been shown to significantly delay the progression of this cancer ( 14 , 15 ). Similarly, insufficient serum vitamin D levels have been shown to lead to a worse melanoma prognosis ( 15 – 18 ). Studies that were not able to reproduce these results have attributed the difference to confounding variables, such as UV radiation and polymorphisms in VDR ( 15 , 19 ).…”

Section: Vitamin D Arsenic and Tumorigenesismentioning

confidence: 99%

Potential association between arsenic and vitamin D

Chittilla,

Uzoma,

Brewer

et al. 2024

Front. Endocrinol.

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“…A vitamin D level < 9.25 ng/mL is another negative independent prognostic factor for survival. It is associated with ulceration formation in melanoma[ 26 ].…”

Section: To the Editormentioning

confidence: 99%

Diagnostic biopsy of cutaneous melanoma, sentinel lymph node biopsy and indications for lymphadenectomy

Pavlidis¹,

Pavlidis²

2022

World J Clin Oncol

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The incidence of cutaneous melanoma appears to be increasing worldwide and this is attributed to solar radiation exposure. Early diagnosis is a challenging task. Any clinically suspected lesion must be assessed by complete diagnostic excision biopsy (margins 1-2 mm); however, there are other biopsy techniques that are less commonly used. Melanomas are characterized by Breslow thickness as thin (< 1 mm), intermediate (1-4 mm) and thick (> 4 mm). This thickness determines their biological behavior, therapy, prognosis and survival. If the biopsy is positive, a wide local excision (margins 1-2 cm) is finally performed. However, metastasis to regional lymph nodes is the most accurate prognostic determinant. Therefore, sentinel lymph node biopsy (SLNB) for diagnosed melanoma plays a pivotal role in the management strategy. Complete lymph node clearance has undoubted advantages and is recommended in all cases of positive SLN biopsy. A PET-CT (positron emission tomography-computed tomography) scan is necessary for staging and follow-up after treatment. Novel targeted therapies and immunotherapies have shown improved outcomes in advanced cases.

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[Translated article] Prognostic Value of Vitamin D Serum Levels in Cutaneous Melanoma

Cited by 3 publications

References 17 publications

Vitamin D in Melanoma: Potential Role of Cytochrome P450 Enzymes

Vitamin D in Melanoma: Potential Role of Cytochrome P450 Enzymes

Potential association between arsenic and vitamin D

Diagnostic biopsy of cutaneous melanoma, sentinel lymph node biopsy and indications for lymphadenectomy

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