Transitions from first substance use to substance use disorders in adolescence: Is early onset associated with a rapid escalation?

Behrendt, Silke; Wittchen, Hans‐Ulrich; Höfler, Michael; Lieb, Roselind; Beesdo, Katja

doi:10.1016/j.drugalcdep.2008.06.014

Cited by 309 publications

(249 citation statements)

References 52 publications

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“…Sensitivity to reward has been shown to be associated with a stronger physiological response to alcohol intake as well as an increase in conditioned responses to alcohol cues (Brunelle et al, 2004). In addition, early initiation of alcohol intake was found to be associated with an elevated risk for the development of alcohol use disorder (Behrendt et al, 2009), specifically in adolescence, since this period was characterized as a high risk period for first alcohol use and the transition to alcohol abuse and dependence (Wittchen et al, 2008;Swendsen et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

“…Following the present findings, risk for early onset of drinking may be mediated by various aspects on a psychological and neurobiological level, with a quite high proportion of explained variance (ie, up to 26%). Since early initiation of alcohol intake, even at very low levels of alcohol use, was found to be associated with an elevated risk for the development of alcohol use disorder (Behrendt et al, 2009), this might represent a risk factor for later development of alcohol addiction. In addition, although the number of subjects scoring in zone II in the AUDIT was very small, our data also suggest that problem drinking may be differentially mediated by personality, behavioral, and neural responses.…”

Section: Discussionmentioning

confidence: 99%

“…Early initiation of alcohol intake, even at very low levels of alcohol use, was found to be associated with an elevated risk for the development of alcohol use disorder (Behrendt et al, 2009). Specifically, adolescence was characterized as a high risk period for first alcohol use and the transition to alcohol abuse and dependence (Wittchen et al, 2008;Swendsen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Nees

Tzschoppe

Patrick

et al. 2011

Neuropsychopharmacol

126

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Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N ¼ 324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Nees

Tzschoppe

Patrick

et al. 2011

Neuropsychopharmacol

126

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“…They do it both to relieve stress after a traumatic event and to reduce the psycho-emotional stress caused by various factors, including studies, the need to work, maturing, etc. (Johnston, O'Malley, Miech, Bachman, & Schulenberg, 2015;Ham, Wiersma-Mosley, Feldner, Melkonian, Milner, & Lewis, 2016;Avant, Davis, & Cranston, 2011;Behrendt, Wittchen, Höfler, Lieb, & Beesdo, 2009). "Fifty percent of adolescents have tried an illicit drug and 70 % have tried alcohol by the end of high school, with even higher rates among multiracial youth" (Fisher, Zapolski, Sheehan, & Barnes-Najor, 2017, p. 27).…”

Section: Introductionmentioning

confidence: 99%

Evaluation Of Psycho-Emotional Health Of Students Of University City In Siberia

Arlyapova¹,

Kashpur²,

Konyukhova³

et al. 2018

The European Proceedings of Social and Behavioural Sciences

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Many university students smoke, drink alcohol, and use various psychoactive substances. Among them there are people who have problems with addition to these substances. Some can not cope with it and they need help from psychologists or health professionals. Increased psycho-emotional loads become a frequent reason for using psychoactive substances. The purpose of the study was to identify the facts of non-medical use of narcotic drugs and other psychotropic substances by students of a university city, and to establish reasons for it. The study was conducted in March-June 2015 among students of a university city in Western Siberia. 22 199 students aged 18 to 25 were examined by the method of a continuous survey. The average age of the respondents at the time of the study was 20.9. The authors found that the main problems of students are related to their status and social role: household difficulties, high study loads, the need to make their own money (work and study). Great pressure in these spheres can provoke a desire to relieve tension by smoking, drinking alcohol, using narcotic or other psychotropic substances.The result of the study proves that the problem of the emotional security of the educational environment is broader than the prevention of smoking, alcoholism and drug addiction. Today high loads of the university study provoke stress and endogenous diseases that in their symptoms, without clinical studies, coincide with addiction and withdrawal symptoms.

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“…Cannabis dependence develops twice as rapidly in adolescents than adults at any consumption level [6][7][8][9]; approximately 14-16% adolescentonset and 8% adult-onset users become dependent [3]. While early cannabis initiation and entrenched use confer the highest risk of dependence and other adverse outcomes [7][8][9][10][11], even occasional (weekly) use continued into young adulthood predicts later drug and other problems [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Cannabis Use and Disorder Transitions Among a Mixed Community Sample of At-Risk Adolescents and Adults: A Prospective New Zealand Study

Bashford¹,

Copeland²,

Flett³

2013

TOADDJ

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Introduction and Aims:The trajectories of cannabis use disorder (CUD) require more comprehensive delineation to expedite recognition of incubating dependence among high-risk users. This study examined baseline cannabis use and CUD over 12 months using DSM-IV/ICD10 diagnoses to distinguish transition groups. Design and Methods:In a prospective naturalistic design, 194 heterogeneous cannabis users (128 adolescents, 66 adults) aged 13-61 years were voluntarily recruited and assessed at baseline, and then re-assessed 12-months later.Results: Most participants met criteria for a baseline CUD (70% dependence, 20% abuse), 12 adolescents were 'diagnostic orphans', and 5 symptom-free. At follow-up, 25% adolescents reported using less, 6% the same level, and 69% using more cannabis. Significantly increased symptoms and dependence severity were reported, with no adolescent/adult differences evident. Three diagnostic transition groups were identified. While 84% adolescents (n=108) remained stable, 5% (n=7) had improved, 10% (n=13) had deteriorated. 'Deteriorators' scored significantly higher than 'improvers' on cannabis use, symptoms, and dependence severity measures. A subjective loss of control over cannabis use was among the earliest DSM-IV features among younger users on a trajectory towards dependence. Most participants (79%) anticipated difficulty trying to reduce/quit their use Discussion and Conclusions: Younger adolescents can rapidly develop cannabis dependence, reporting similar and equally severe symptoms as longer-term adult users. Impaired control over use occurs early in trajectories towards dependence. The seeming intractability of problematic cannabis use calls for concerted cannabis screening and early intervention (SEI) efforts at an earlier age to avert or reduce harmful consequences of cannabis use in the community.

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Transitions from first substance use to substance use disorders in adolescence: Is early onset associated with a rapid escalation?

Cited by 309 publications

References 52 publications

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Determinants of Early Alcohol Use In Healthy Adolescents: The Differential Contribution of Neuroimaging and Psychological Factors

Evaluation Of Psycho-Emotional Health Of Students Of University City In Siberia

Cannabis Use and Disorder Transitions Among a Mixed Community Sample of At-Risk Adolescents and Adults: A Prospective New Zealand Study

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