Transitions between neocortical seizure and non-seizure-like states and their association with presynaptic glutamate release

Breton, Vanessa L.; Dufour, Suzie; Chinvarun, Yotin; Campo, J. Martin del; Bardakjian, Berj L.; Carlen, Peter L.

doi:10.1016/j.nbd.2020.105124

Cited by 2 publications

(4 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was in contrast to the high frequency component, which showed a reversal potential of −36 ± 9.8 mV. This indicated that excitation, likely glutamatergic, is dominant in these pyramidal neurons at the onset of the bursts ( Breton et al, 2020 ).…”

Section: Resultsmentioning

confidence: 95%

See 1 more Smart Citation

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Breton

Aquilino

Repudi

et al. 2021

Neurobiology of Disease

Self Cite

View full text Add to dashboard Cite

Summary Loss of function mutations of the WW domain-containing oxidoreductase ( WWOX ) gene are associated with severe and fatal drug-resistant pediatric epileptic encephalopathy. Epileptic seizures are typically characterized by neuronal hyperexcitability; however, the specific contribution of WWOX to that hyperexcitability has yet to be investigated. Using a mouse model of neuronal Wwox -deletion that exhibit spontaneous seizures, in vitro whole-cell and field potential electrophysiological characterization identified spontaneous bursting activity in the neocortex, a marker of the underlying network hyperexcitability. Spectral analysis of the neocortical bursting events highlighted increased phase-amplitude coupling, and a propagation from layer II/III to layer V. These bursts were NMDAR and gap junction dependent. In layer II/III pyramidal neurons, Wwox knockout mice demonstrated elevated amplitude of excitatory post-synaptic currents, whereas the frequency and amplitude of inhibitory post-synaptic currents were reduced, as compared to heterozygote and wild-type littermate controls. Furthermore, these neurons were depolarized and demonstrated increased action potential frequency, sag current, and post-inhibitory rebound. These findings suggest WWOX plays an essential role in balancing neocortical excitability and provide insight towards developing therapeutics for those suffering from WWOX disorders.

show abstract

Section: Resultsmentioning

confidence: 95%

“…1 D). Burst duration and inter-burst interval were plotted using the histfit.m function in Matlab, fitting the data to a gamma distribution ( Breton et al, 2020 ).…”

Section: Signal Processingmentioning

confidence: 99%

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Breton

Aquilino

Repudi

et al. 2021

Neurobiology of Disease

Self Cite

View full text Add to dashboard Cite

show abstract

“… 4 New research from Breton and colleagues provides further evidence for the importance of glutamatergic synaptic vesicle pool depletion in regulating ictal to interictal transitions. 5 …”

Section: Commentarymentioning

confidence: 99%

“…4 New research from Breton and colleagues provides further evidence for the importance of glutamatergic synaptic vesicle pool depletion in regulating ictal to interictal transitions. 5 To investigate this, the authors performed electrophysiological recordings in acute cortical slices bathed in a Mg ++ -free solution. As a starting point, however, they trained a 2-state Hidden Markov Model with delta (0.5 to 3 Hz) and gamma (30 to 80 Hz) spectral features collected from either patient EEG or local field potential recordings from their slices.…”

Section: Commentarymentioning

confidence: 99%

Glutamate’s Secret Interictal Life

Cullen¹,

Weston²

2021

Epilepsy Curr

View full text Add to dashboard Cite

Transitions between neocortical seizure and non-seizure-like states and their association with presynaptic glutamate release

Cited by 2 publications

References 69 publications

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

Glutamate’s Secret Interictal Life

Contact Info

Product

Resources

About