Clinical practice guidelines outline appropriate and evidence-based approaches for the management of medical conditions and performance of clinical procedures. Guidelines are typically developed with the goal of minimizing variations in clinical practice, improving quality of care, reducing litigation risk, optimizing health outcomes, and helping to control cost. The term ''transitions of care'' refers to specific interactions, communication, and planning that are required if patients are to move in a safe and orderly manner from one service or setting to another. Transitions occur between inpatient and outpatient settings and within hospitals, from initial presentation in the emergency department, through hospitalization, and back to the community or possibly to subacute care facilities. The objective of this article is to review processes for developing and validating institutional protocols that focus on management, communication, and transitions of care for ACS patients.Keywords Acute coronary syndrome Á ACS protocols Á ACS management Á Emergency and hospital medicine Á Acute coronary syndrome protocols Á Acute coronary syndrome management Á ASC care and management