Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan

Nakano, Yasuhiro; Otsuka, Yuki; Honda, Hiroyuki; Sunada, Naruhiko; Tokumasu, Kazuki; Sakurada, Yasue; Matsuda, Yui; Hasegawa, Tomohiko; Ochi, Kanako; Hagiya, Hideharu; Kataoka, Hitomi; Ueda, Keigo; Otsuka, Fumio

doi:10.3390/medicina58101393

Cited by 15 publications

(15 citation statements)

References 31 publications

(39 reference statements)

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“…At the beginning of the year 2022, the Omicron variant became the predominant cause of the disease [ 130 ]. Infection with the Omicron variant caused milder disease with much fewer need for hospitalization [ 131 , 132 ]. There were less frequent lower respiratory tract infections caused by the Omicron variant and thus less frequent severe forms of the disease were observed [ 133 ].…”

Section: Continuing Mutation Of Sars-cov-2mentioning

confidence: 99%

“…In addition, the probability of symptoms persisting beyond two months in the patients infected with the Omicron variant appeared to be diminished as compared with ancestral COVID-19 [ 134 , 135 ]. Long-COVID symptoms in the patients infected in the period of the Omicron variant predominance differed from the symptoms in the patients infected in the period of predominant Delta variant, with a higher incidence of cough (20% vs. 7%), fatigue and insomnia, and lower incidence of dysosmia and dysgeusia [ 131 ].…”

Section: Continuing Mutation Of Sars-cov-2mentioning

confidence: 99%

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Cardiovascular, Pulmonary, and Neuropsychiatric Short- and Long-Term Complications of COVID-19

Kobusiak−Prokopowicz

Fułek

et al. 2022

Cells

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Beginning with the various strategies of the SARS-CoV-2 virus to invade our bodies and manifest infection, and ending with the recent long COVID, we are witnessing the evolving course of the disease in addition to the pandemic. Given the partially controlled course of the COVID-19 pandemic, the greatest challenge currently lies in managing the short- and long-term complications of COVID-19. We have assembled current knowledge of the broad spectrum of cardiovascular, pulmonary, and neuropsychiatric sequelae following SARS-CoV-2 infection to understand how these clinical manifestations collectively lead to a severe form of the disease. The ultimate goal would be to better understand these complications and find ways to prevent clinical deterioration.

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Section: Continuing Mutation Of Sars-cov-2mentioning

confidence: 99%

Section: Continuing Mutation Of Sars-cov-2mentioning

confidence: 99%

Cardiovascular, Pulmonary, and Neuropsychiatric Short- and Long-Term Complications of COVID-19

Kobusiak−Prokopowicz

Fułek

et al. 2022

Cells

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“…According to our epidemiological classification of COVID-19 in Okayama Prefecture in Japan, [ 12 ] we divided the patients’ onset of COVID-19 into three groups: the Preceding phase is the period from the ancestral variant to the Alpha variant, before 18 July 2021; the Delta variant phase is the period from 19 July 2021 to 31 December 2021, when the Delta variant was dominant after the Alpha variant phase; and the Omicron variant phase is the period after 1 January 2022, when the Omicron variant was dominant in Okayama Prefecture [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Trends in Long COVID Symptoms in Japanese Teenage Patients

et al. 2023

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Background: Since the start of the global pandemic of coronavirus disease 2019 (COVID-19), not only adults but also many children have suffered from it. However, the clinical characteristics of long COVID in children remain unclear. Methods: In this retrospective observational study conducted in a single facility, we reviewed the medical records of all long COVID patients who visited Okayama University Hospital from February 2021 to October 2022, and we compared the clinical characteristics of long COVID in teenagers (11 to 18 years of age) with those in adults. Results: Data for 452 long COVID patients including 54 teenagers (11.9%) were analyzed. Fatigue was the most frequent symptom in teenagers (55.6% of the patients) and also in adults. On the other hand, the percentage of teenagers who complained of headache, which was the second most frequent complaint, was significantly higher than the percentage of adults (35.2% vs. 21.9%, p < 0.05). A comparison of the frequencies of symptoms depending on the viral variant showed that fatigue and headache were predominant symptoms in the Omicron variant phase. Of the 50 teenagers who were enrolled in schools, 28 (56.0%) could not attend school due to long COVID symptoms. The most common symptoms as reasons for absence from school were fatigue (85.7% of the patients), headache (42.9%), and insomnia (32.1%). Conclusions: Attention should be paid to the symptoms of fatigue and headache in teenagers with long COVID.

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“…The presence of "brain fog" symptoms was carefully determined by individual interview, based on complaints of the subjective feeling of concentration difficulty and impaired ability to concentrate and/or think; namely, being mentally slow, fuzzy, or spaced out, affecting the patient's ability to think or concentrate with a dull headache [16]. The onset of COVID-19 in the patients was divided into three groups based on the epidemiological aspects of COVID-19 in Okayama Prefecture in Japan: preceding period; Delta-dominant period; and Omicron-dominant period [11]. The preceding period is the period from the ancestral strain to the Alpha strain, before 18 July 2021; the Delta-dominant period is the period from 19 July 2021 to 31 December 2021, when the Delta variants were dominant after the Alpha-dominant phase; and the Omicron-dominant period is the period after 1 January 2022, when the Omicron variants were dominant in Okayama Prefecture, Japan.…”

Section: Study Design and Inclusion Of Patientsmentioning

confidence: 99%

“…It was found that the major complaints in the early period of the COVID-19 pandemic were fatigue and anxiety [9] and that the severity of the infection status affected the number and duration of persistent symptoms [10]. The frequency of each symptom of long COVID has been changing with the emergence of new variants of SARS-CoV-2 [11]. Moreover, we have shown that endocrine factors including anterior pituitary, adrenal and thyroid hormones [12], and male androgen levels [13,14] might be related to the fatigue symptoms of long COVID.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan

Sunada

Nakano

Otsuka

et al. 2022

JCM

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Objectives: The objective of this study was to determine the clinical and endocrinological features of sleep disturbance in patients with long COVID. Methods: This study was a single-center retrospective observational study for patients who visited the COVID-19 aftercare outpatient clinic (CAC) established in Okayama University Hospital in Japan during the period from 15 February 2021 to 29 July 2022. The long COVID patients were divided into two groups based on the presence or absence of sleep disturbance, and the clinical and laboratory characteristics of the patients were analyzed. Results: Out of 363 patients with long COVID, after excluding 6 patients, 60 patients (16.5%) (55% males, median age of 38 years) complaining of sleep disturbance were compared with 303 patients (83.5%) (43% males, median age of 40 years) without sleep-related symptoms. Although there were no significant differences in clinical backgrounds and severities of COVID-19 between the two groups by the multivariate analysis, the percentage of long COVID patients with sleep disturbance was significantly increased among patients infected in the Omicron-dominant phase. In addition, the prevalence rate of sleep disturbance in patients when infected in the Omicron phase (24.8%) was two-times higher than that in patients infected in the Delta phase (12.8%). Of note, the percentages of patients with sleep disturbance who also complained of general fatigue, headache, concentration loss, anxiety, low-grade fever, and brain fog symptoms were higher than the percentages of patients without sleep disturbance who had the same complaints. Among the types of sleep disturbance, the percentage of patients who complained of loss of sleep induction (75%) was much higher than the percentage of patients with early-awakening sleep disturbance (6.7%), and many of the patients with mid-awakening types of insomnia had brain fog symptoms. Endocrine examinations revealed that long COVID patients with sleep disturbance had significantly higher levels of plasma adrenocorticotropin and lower levels of serum growth hormone, suggesting the presence of hypothalamic–pituitary stress. Conclusion: The prevalence of sleep disturbance has been increasing in long COVID patients infected in the Omicron phase with a certain clinical and endocrine trend.

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Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan

Cited by 15 publications

References 31 publications

Cardiovascular, Pulmonary, and Neuropsychiatric Short- and Long-Term Complications of COVID-19

Cardiovascular, Pulmonary, and Neuropsychiatric Short- and Long-Term Complications of COVID-19

Trends in Long COVID Symptoms in Japanese Teenage Patients

Characteristics of Sleep Disturbance in Patients with Long COVID: A Retrospective Observational Study in Japan

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