Transitional Cell Tumors of the Renal Pelvis in Analgesic Abusers

Bengtsson, U.; Angervall, Lennart; Ekman, H; Lehmann, Leif

doi:10.3109/00365596809135358

Cited by 153 publications

(28 citation statements)

References 3 publications

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“…The association between analgesic abuse and transitional cell tumors of the urinary tract was first reported by Bengtsson et al [17] and later confirmed by many authors. In addition, analgesic nephropathy is, albeit less strongly, associated with renal cell tumors [18,58].…”

Section: Medicationmentioning

confidence: 69%

“…In about 10-20% of dialysis patients long-term analgesic abuse is the cause of renal failure, which may be associated with urothelial carcinomas as well as renal cell carcinomas in particular after renal transplantation [17,18]. In a study carried out in 65 patients after renal transplantation due to analgesic nephropathy the following cancers were observed: urothelial carcinoma in 15.4%, bladder cancer in 10.8%, and pelvic cancer in 9.1% [19].…”

Section: Renal Diseases As Predisposing Factors Of Cancers Of the Kidmentioning

confidence: 99%

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Cancer in End-Stage Renal Disease: Potential Factors Involved

Vamvakas

Bahner²,

Heidland³

1998

Am J Nephrol

166

113

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Increased incidence of cancer at various sites is observed in patients with end-stage renal disease (ESRD). In particular, lymphomas and carcinomas of the kidney, prostate, liver and uterus show an enhanced prevalence in these subjects compared with the general population. A multitude of factors directly or indirectly associated with the renal disease and the treatment regimens may contribute to the increased tumor formation in these patients. Impaired function of the immune system and of DNA repair mechanisms as well as reduced antioxidant defense, accumulation of carcinogenic compounds partly due to reduced renal elimination as well as chronic infections and inflammations are found more frequently in patients with ESRD compared with the general population and may act in concert to accelerate malignant transformation and tumor formation.

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Section: Medicationmentioning

confidence: 69%

Section: Renal Diseases As Predisposing Factors Of Cancers Of the Kidmentioning

confidence: 99%

Cancer in End-Stage Renal Disease: Potential Factors Involved

Vamvakas

Bahner²,

Heidland³

1998

Am J Nephrol

166

113

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“…Chronic use of analgesics was first linked to the development of kidney cancer through a series of case reports which documented cancer of the renal pelvis occurring in heavy users of phenacetin (Bengtsson et al, 1968;Mahony et al, 1977). These uncontrolled observations were later confirmed by a number of case-control studies conducted in diverse populations (McCredie et al, 1982;McLaughlin et al, 1985;Jensen et al, 1989).…”

mentioning

confidence: 98%

Regular use of analgesics is a risk factor for renal cell carcinoma

et al. 1999

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Summary Phenacetin-based analgesics have been linked to the development of renal pelvis cancer and renal cell carcinoma (RCC). The relationship between non-phenacetin types of analgesics and kidney cancer is less clear, although laboratory evidence suggests that these drugs possess carcinogenic potential. A population-based case-control study involving 1204 non-Asian RCC patients aged 25-74 and an equal number of sex-, age-and race-matched neighbourhood controls was conducted in Los Angeles, California, to investigate the relationship between sustained use of analgesics and risk of RCC according to major formulation categories. Detailed information on medical and medication histories, and other lifestyle factors was collected through in-person interviews. Regular use of analgesics was a significant risk factor for RCC in both men and women (odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.4-1.9 for both sexes combined). Risks were elevated across all four major classes of analgesics (aspirin, non-steroidal anti-inflammatory agents other than aspirin, acetaminophen and phenacetin). Within each class of analgesics, there was statistically significant increasing risk with increasing level of exposure. Although there was some minor variability by major class of formulation, in general individuals in the highest exposure categories exhibited approximately 2.5-fold increase in risk relative to non-or irregular users of analgesics. Subjects who took one regular-strength (i.e. 325 mg) aspirin a day or less for cardiovascular disease prevention were not at an increased risk of RCC (OR = 0.9, 95% CI = 0.6-1.4).

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“…These patients have thus been exposed to a longer period of uremia than those with other diagnoses such as glomerulonephritis, nephrosclerosis, or diabetes. An increased incidence of renal, bladder, and other cancers have been reported in patients with polycystic kidney disease and pyelonephritis (analgesic abuse), possi bly apart from uremia [14][15][16], The relationship between the primary disease, uremia and renal and bladder carci noma in these particular patients thus becomes very complex. However, only 1 case of renal cancer was observed in the patients with polycystic kidney disease, and all reports cited above exclude cases where the malignancy caused renal failure.…”

mentioning

confidence: 99%

“…Slifkin el at. [16] analyzed 712 patients who were started on mainte nance hemodialysis and found 23 cancers in 22 patients. When these patients were compared to an age-matched group, there was no increased incidence of malignancy.…”

mentioning

confidence: 99%

Are Malignancies Increased in Uremia?

Kjellstrand¹

1979

Nephron

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Transitional Cell Tumors of the Renal Pelvis in Analgesic Abusers

Cited by 153 publications

References 3 publications

Cancer in End-Stage Renal Disease: Potential Factors Involved

Cancer in End-Stage Renal Disease: Potential Factors Involved

Regular use of analgesics is a risk factor for renal cell carcinoma

Are Malignancies Increased in Uremia?

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