Transitional Cell Carcinoma of the Native Urinary Tract After Kidney Transplantation: Recommendations Following a Long-Term Retrospective Analysis

Tsaur, Igor; Karalis, Athanasios; Blaheta, Roman A.; Juengel, Eva; Vallo, Stefan; Probst, M.; Scheuermann, Ernst-Heinrich; Obermüller, Nicholas; Kachel, Heinz-Georg; Waaga-Gasser, A. M.; Chandraker, Anil

doi:10.1097/maj.0b013e31820a87f7

Cited by 17 publications

(18 citation statements)

References 24 publications

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“…The mean survival of RTRs with UC is significantly lower compared with RTRs without UC (34 months vs 222 months, respectively) 2. The 1, 5 and 10 year overall survival is 80%, 54%, 30%, respectively, and the 1, 5 and 10 year tumour-specific survival is 85%, 67% and 58%, respectively 3. The most frequent sites of UUT-UC metastasis are, in descending order of frequency, the lymph nodes, lung, liver, bone and peritoneum 20.…”

Section: Discussionmentioning

confidence: 98%

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Urothelial carcinoma of an allograft ureter 10 years after deceased donor kidney transplantation

Gaughan¹,

Haroon

Davis

et al. 2018

BMJ Case Reports

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The incidence of urothelial carcinoma (UC; formerly transitional cell carcinoma) is higher among renal transplant recipients compared with the general population. Upper urinary tract UC (UUT-UC) of allograft urothelium is a rare event with approximately 40 cases reported in the literature. Herein, we describe the clinical presentation and management of UUT-UC in a transplant ureter 10 years after deceased donor kidney transplantation.

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Section: Discussionmentioning

confidence: 98%

“…Tsaur et al has proposed a vigilant screening process involving annual cystoscopies in RTRs with at least one significant risk factor for UC 3. We would advocate that a screening protocol should at least consist of regular urinalysis and ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

Urothelial carcinoma of an allograft ureter 10 years after deceased donor kidney transplantation

Gaughan¹,

Haroon

Davis

et al. 2018

BMJ Case Reports

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“…In China and Taiwan, the proportion of UCs in KTRs is unusually high: 0.9–4.1% versus 0.1–1.1% in other regions (Table 3) [33–51]. Impaired immunity due to immunosuppressants, viral infection, and uremia has been proposed as a risk factor for the development of malignancies in KTRs [35], which have a malignancy incidence rate approximately 4-5-fold higher than that for the general population [35, 50, 52].…”

Section: Upper Tract Urothelial Carcinomas In Kidney Transplant Rementioning

confidence: 99%

“…Early recurrence in the urinary bladder or contralateral upper urinary tract is also common in UCs in KTRs in China and Taiwan [33–42]. These features of UCs in KTRs in China and Taiwan are quite different from those of the predominant bladder UCs and from the male predominance of UCs observed for KTRs in other areas [33–51]. …”

Section: Upper Tract Urothelial Carcinomas In Kidney Transplant Rementioning

confidence: 99%

“…In contrast, noninvasive UTUCs are associated with low recurrence and mortality rates [46, 47]. UCs in KTRs present with a wide variety of symtoms or are sometimes asymptomatic [37–40, 51, 53]. Painless gross hematuria represents the most common symptom, followed by microscopic hematuria and chronic urinary tract infection [37–40, 51, 53].…”

Section: Upper Tract Urothelial Carcinomas In Kidney Transplant Rementioning

confidence: 99%

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Upper Tract Urothelial Carcinomas in Patients with Chronic Kidney Disease: Relationship with Diagnostic Challenge

Wang

Lee

Teh

et al. 2014

BioMed Research International

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Chronic kidney disease and upper tract urothelial carcinomas display a bidirectional relationship. Review of the literature indicates that early diagnosis and correct localization of upper tract urothelial carcinomas in dialysis patients and kidney transplant recipients are important but problematic. Urine cytology and cystoscopy have limited sensitivity for the diagnosis of upper tract urothelial carcinomas in dialysis patients. Enhanced computed tomography and magnetic resonance imaging could prove useful for the detection and staging of upper tract urothelial carcinomas in dialysis patients. Renal ultrasound can detect hydronephrosis caused by upper tract urothelial carcinomas in kidney transplant recipients but cannot visualize the carcinomas themselves. High detection rates for upper tract urothelial carcinomas in kidney transplant recipients have recently been demonstrated using computed tomography urography, which appears to be a promising tool. To detect carcinomas in dialysis patients and kidney transplant recipients as early as possible, regular screening in asymptomatic patients and diagnostic work-up in symptomatic patients should be performed using a combination of urological and imaging methods. Careful assessment of subsequent recurrence within the contralateral upper urinary tract and the urinary bladder is necessary for dialysis patients and kidney transplant recipients with upper tract urothelial carcinomas.

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Factores de riesgo, manejo y supervivencia del cáncer vesical después de trasplante renal

Jue

Alameddine

González

et al. 2021

Actas Urológicas Españolas

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Transitional Cell Carcinoma of the Native Urinary Tract After Kidney Transplantation: Recommendations Following a Long-Term Retrospective Analysis

Cited by 17 publications

References 24 publications

Urothelial carcinoma of an allograft ureter 10 years after deceased donor kidney transplantation

Urothelial carcinoma of an allograft ureter 10 years after deceased donor kidney transplantation

Upper Tract Urothelial Carcinomas in Patients with Chronic Kidney Disease: Relationship with Diagnostic Challenge

Factores de riesgo, manejo y supervivencia del cáncer vesical después de trasplante renal

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