Transitional Cell Carcinoma of the Bladder Manifestating as Malignant Lymphoma with Generalized Lymphadenopathy

Abstract

Bladder cancer usually spreads via the lymphatic and hematogenous routes, the most common sites of metastases of urinary bladder cancers being the regional lymph nodes, liver, lung, bone, peritoneum, pleura, kidney, adrenal gland and intestines. Generalized lymph node metastasis of transitional cell cancer of the bladder is extremely rare. According to our literature search, there has been no case report of transitional cell cancer of the bladder that manifests as an extensive large lymph node metastasis involving the intraparotid, supraclavicular thoracic inlet, axillary and regional abdominal and pelvic lymph nodes without bone or visceral organs involved. Such a presentation could be mistaken as malignant lymphoma and the importance of a biopsy of the lymph nodes is emphasized. The clinical course of rapid progression of the disease and the presence of wild-type p53 with rapid response to chemotherapy and a short remission may represent a unique case, which is discussed here.

Supraclavicular Metastasis from Infraclavicular Organs: Retrospective Analysis of 18 Patients

“…5 cinoma for frequency and location of metastasis. Urinary urothelial carcinoma could rarely occur in a lymphomalike pattern with supraclavicular lymph node involvement (22). For supraclavicular metastasis of urothelial cancer, there were no reported cases for curative neck dissection in the literature.…”

Transitional cell carcinoma of urinary bladder manifesting as extensive retroperitoneal and axillary lymph node metastasis: An extremely rare case scenario detected by 18F-fluorodeoxyglucose positron emission tomography scan

“…Kancharla et al . [ 7 ] in 2010 reported the first case of TCC bladder with retroperitoneal and axillary lymphadenopathy where the patient had initially presented with hematuria and was later diagnosed to have disseminated lymphadenopathy. Our case is the first case where an asymptomatic patient presented with upfront massive axillary LN metastasis and retroperitoneal lymphadenopathy detected by 18 F-FDG PET.…”

Cervical lymph node metastasis from transitional cell carcinoma of urinary bladder: Case report and review of literature

“…A 9-year review of patients with head and neck metastases from 845 urogenital tract tumors (kidney, prostate, bladder, testes, penis, urethra and ureter) showed that only 31 (3.7%) of these tumors developed metastases to the cervical and supraclavicular lymph nodes [6] . There has been one case report of transitional cell cancer of the bladder is mentioned that manifested as an extensive large lymph node metastasis involving the intraparotid, supraclavicular, axillary and regional abdominal and pelvic lymph nodes without bone or visceral organs involved [7] .…”