Transitional cell carcinoma of the urinary bladder with osteoclast‐type giant cells: a report of two cases and review of the literature

Zukerberg, Lawrence; Armin, Ali-Reza; Pisharodi, Latha; Young, Robert H.

doi:10.1111/j.1365-2559.1990.tb00760.x

Cited by 36 publications

(25 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Osteoclast-like giant cells are a rare finding in poorly differentiated or metaplastic carcinomas of breast, thyroid, pancreas, and other organs [5,8,13,15,22,24,29]. They most likely represent reactive stromal elements of histiocytic origin, microscopically indistinguishable from true osteoclasts.…”

Section: Discussionmentioning

confidence: 99%

Benign tumors of the breast with multinucleated stromal giant cells

2001

View full text Add to dashboard Cite

The authors present six cases of benign tumors of the breast with numerous multinucleated stromal giant cells (MSGC). All six patients were women aged 37-70 years (mean 48 years), presenting clinically with a breast mass 1.0-3.8 cm in size (mean 1.9 cm; median 1.5 cm). By standard H&E examination, all cases showed the presence of numerous MSGC haphazardly dispersed within the tumor stroma. Three cases revealed MSGC merging into the surrounding adipose tissue simulating infiltrative growth. The MSGC appeared to have multiple nuclei (5 to 25) with fine chromatin and sporadic small nucleoli. Their cytoplasm was inconspicuous. The MSGC expressed vimentin only and to lesser extent CD34. These cells were negative for muscle markers, keratins, S-100 protein, vascular markers, CD68 and hormone receptors. Interestingly, the majority of MSGC and mononuclear stromal cells showed reactivity for p53 protein and Ki-67 proliferation antigen. All patients were treated by simple excision and remain free of recurrence (mean 70 months, median 48 months.). The reactivity of p53 in MSGC and mononuclear stromal cells may play a key role in linking these two cell types. Nonetheless, the presence of MSGC does not alter prognosis of otherwise typical benign lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Benign tumors of the breast with multinucleated stromal giant cells

2001

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8][9] To the best of our knowledge, less than 20 case reports (maximum two cases per report) of osteoclast-like giant-cell tumor of the urothelial tract have been published in the English literature. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Our study is the largest series in the literature of osteoclast-like giant-cell tumors arising in the urinary tract, and includes six patients. The current study was undertaken to more fully define the clinical and pathologic features of these tumors, and to utilize antibodies to CD51 and CD54, specific markers for osteoclasts, to shed light into their histogenesis.…”

mentioning

confidence: 99%

Osteoclast-rich undifferentiated carcinomas of the urinary tract

2006

View full text Add to dashboard Cite

Osteoclast-like giant-cell neoplasms of the urinary tract are rare. They are composed of ovoid or spindle-shaped mononuclear cells with evenly spaced osteoclast-like giant cells. Terminology, histogenesis, and biologic behavior of these tumors remain controversial. Six cases of osteoclast-like giant-cell neoplasms of the urinary tract were identified from the consultation files of two of the authors. Patients were all male and elderly (range 65-82), with the exception of one 39-year-old male. In all, 3/6 tumors developed in the bladder and 3/6 in the renal pelvis. Size ranged from 5 to 11 cm. One bladder and three renal pelvis tumors were high stage (pT3) at time of presentation. Adjacent to the osteoclast-like giant-cell neoplasm in the same specimen, all patients had urothelial carcinoma in situ and/or high-grade papillary urothelial carcinoma. Multinucleated cells had identical morphological and immunohistochemical properties of osteoclasts; positive for CD-68, LCA, CD51 and CD54, and negative for cytokeratins and EMA. Varying percentages of mononuclear cells expressed a-smooth muscle actin (4/6), desmin (1/6), S-100 (4/6), LCA (2/6) and CD68 (6/6). However, mononuclear cells were also positive for epithelial markers in 4/6 tumors (cytokeratins AE-1/AE-3, Cam 5.2, CK7 and/or EMA). p53 stained mononuclear tumor cells in three cases, paralleling the staining on the accompanying urothelial carcinoma. Ki-67 stained mononuclear tumor cells, but not osteoclast-like giant cells. Follow-up data were available in five cases. One patient developed recurrence of noninvasive urothelial carcinoma and is still alive. Four patients were dead due to disease within 15 months, three with distant metastases. The intimate association of these tumors with urothelial carcinoma along with their immunohistochemical profile supports an epithelial origin for the mononuclear cells and non-neoplastic reactive histiocytic lineage for the osteoclast-like giant cells.

show abstract

“…However, follow-up periods are very limited (median: 12 months), and no long-term follow-up has been reported. According to Zukerberg and coworkers [4], the presence of osteoclast-like giant cells in bladder carcinoma is supposed to have no adverse effect on the prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…In three of these cases, this phenomenon was regarded as an unusual stromal reaction pattern secondary to urothelial carcinoma [2,4], while a collision tumor of urothelial bladder carcinoma and primary osteoclastoma was assumed in the other three patients [1,3]. The occurrence of abundant osteoclast-like giant cells may cause diagnostic problems, because other differential diagnoses like primary giant cell tumor, giant cell carcinoma or foreign body stromal reaction have to be considered.…”

Section: Introductionmentioning

confidence: 99%

“…The association of osteoclast-like giant cells with urothelial bladder cancer is a very rare event, of which only six cases have been described in the Anglo-American literature [1][2][3][4]. In three of these cases, this phenomenon was regarded as an unusual stromal reaction pattern secondary to urothelial carcinoma [2,4], while a collision tumor of urothelial bladder carcinoma and primary osteoclastoma was assumed in the other three patients [1,3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Papillary Urothelial Bladder Carcinoma Associated with Osteoclast-Like Giant Cells

Krüger

Johannisson

Kausch³

et al. 2005

Int Urol Nephrol

View full text Add to dashboard Cite

We report the case of a papillary urothelial carcinoma associated with osteoclast-like giant cells. A 60-year old woman presented with hematuria. A papillary neoplasm was detected by cystoscopy and removed transurethrally. Histological examination revealed a papillary urothelial carcinoma (grade I) associated with multiple stromal giant cells, which displayed morphological, ultrastructural and immunohistochemical characteristics of osteoclast-like giant cells. The formation of osteoclast-like giant cells in association with urothelial bladder carcinoma is a rare event, of which only six cases have been reported in the Anglo-American literature. It may cause diagnostic problems because primary giant cell tumor, giant cell carcinoma and foreign body stromal reaction have to be considered. Immunohistochemistry and electron microscopy may help to rule out these differential diagnoses.

show abstract

Transitional cell carcinoma of the urinary bladder with osteoclast‐type giant cells: a report of two cases and review of the literature

Cited by 36 publications

References 24 publications

Benign tumors of the breast with multinucleated stromal giant cells

Benign tumors of the breast with multinucleated stromal giant cells

Osteoclast-rich undifferentiated carcinomas of the urinary tract

Papillary Urothelial Bladder Carcinoma Associated with Osteoclast-Like Giant Cells

Contact Info

Product

Resources

About