Transitional Cell Carcinoma involving the Prostate —An Unfavourable Prognostic Sign in the Management of Bladder Cancer?

Kirk, D.; Savage, A; Makepeace, A.R.; Gostelow, B. E.

doi:10.1111/j.1464-410x.1981.tb03272.x

Cited by 18 publications

(3 citation statements)

References 4 publications

(1 reference statement)

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“…Several investigators have referred to pathological factors of bladder cancer related to prostatic transitional cell carcinoma. As to pathological grade or stage, Kirk et al 16 observed no difference in incidence of prostatic involvement among low, average and high‐grade tumors and between superficial and invasive tumors. Matzkin et al 4 also found no correlation between the stage of bladder tumor and the extent of prostatic involvement.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of transitional cell carcinoma of the prostate associated with bladder transitional cell carcinoma

Honda¹,

Yamada²,

Okada³

et al. 2001

Int J of Urology

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Background: Transitional cell carcinoma of the prostate in patients with bladder cancer appears to influence the prognosis and affects the decision about therapeutic modality. Therefore, it is important to characterize transitional cell carcinoma associated with bladder cancer. Methods: From April 1980 to December 1998, 81 male patients underwent total cystoprostatectomies for transitional cell carcinoma of the bladder. The 81 cystoprostatectomy specimens were examined to clarify the characteristics of prostatic involvement by transitional cell carcinoma. The extent, origin, mode of spread and risk factor of prostatic involvement as well as the prognosis were investigated. In 13 of 15 patients with prostatic involvement the prostate was examined by sequential step sections. Results: Prostatic involvement was observed in 15 of 81 patients (18.5%). Prostatic urethral involvement, invasion to prostatic duct/acinus, prostatic stromal invasion and extraprostatic extension and/or seminal vesicle involvement were recognized in 12 (80%), 14 (93.3%), six (40%), and five (33.3%) of the 15 patients, respectively. Twelve of the 15 patients (80%) with prostatic involvement had papillary or non-papillary tumors (i.e. carcinoma in situ) both in the prostatic urethra and prostatic duct. In 10 of these 12 patients (88.3%), there was contiguity between prostatic urethral and ductal tumors. Seven of the 23 patients (30.4%) with carcinoma in situ of the bladder showed prostatic involvement, which increased to 50% in the presence of carcinoma in situ of the trigone or bladder neck. Conclusions: Eighty per cent of the patients with prostatic involvement showed papillary or nonpapillary tumors both in the prostatic urethra and prostatic duct. There was a high level of contiguity between both tumors. Patients with carcinoma in situ of the trigone or bladder neck revealed significantly higher incidence of prostatic involvement.Key words bladder carcinoma, carcinoma in situ of the bladder, prostatic involvement by transitional cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Clinical study of transitional cell carcinoma of the prostate associated with bladder transitional cell carcinoma

Honda¹,

Yamada²,

Okada³

et al. 2001

Int J of Urology

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“…The dangerous growth pattern of primary CIS of Accepted for publication 17 December 1985 the urinary bladder has been described by several authors (Kirk et al, 1981;Utz and Farrow, 1984). Seemayer e?…”

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confidence: 86%

Are Biopsies From the Prostatic Urethra Useful in Patients With Superficial Bladder Carcinoma?

Rikken¹,

Helsdingen²,

Kazzaz³

1987

Journal of Urology

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Fifty male patients entered a Mitomycin C trial for superficial bladder cancer and biopsies in the prostatic urethra were taken with a cold cup biopsy forceps. In one patient this procedure failed. In 2 1 of 49 patients no abnormalities were detected but in the remaining 28 patients (57.1%) histological changes were found in the prostatic urethra. In 13 of these patients (26.5%) the changes were either carcinoma in situ (CIS) or superficial bladder carcinoma.Carcinoma in situ in the prostatic urethra was found in nine patients ( 18%) and in all but one it was combined with CIS in the bladder.These results indicate that biopsies from the prostatic urethra must be taken routinely in order to plan adequate therapy.

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“…Most studies on bladder urothelial carcinomas infiltrating the prostate have been done on samples of cystoprostatectomy. The frequency of infiltration varies between 12 and 55% depending on the series ( 1 – 5 ). In most cases the infiltrating urothelial tumors are high grade and are associated with a poor prognosis, even when detected in early stages ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

Low grade urothelial carcinoma mimicking basal cell hyperplasia and transitional metaplasia in needle prostate biopsy

et al. 2016

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PurposeThe vast majority of urothelial carcinomas infiltrating the bladder are consistent with high-grade tumors that can be easily recognized as malignant in needle prostatic biopsies. In contrast, the histological changes of low-grade urothelial carcinomas in this kind of biopsy have not been studied.Materials and MethodsWe describe the clinicopathologic features of two patients with low-grade bladder carcinomas infiltrating the prostate. They reported dysuria and hematuria. Both had a slight elevation of the prostate specific antigen and induration of the prostatic lobes. Needle biopsies were performed. At endoscopy bladder tumors were found in both cases.ResultsBoth biopsies showed nests of basophilic cells and cells with perinuclear clearing and slight atypia infiltrating acini and small prostatic ducts. The stroma exhibited extensive desmoplasia and chronic inflammation. The original diagnosis was basal cell hyperplasia and transitional metaplasia. The bladder tumors also showed low-grade urothelial carcinoma. In one case, the neoplasm infiltrated the lamina propria, and in another, the muscle layer. In both, a transurethral resection was performed for obstructive urinary symptoms. The neoplasms were positive for high molecular weight keratin (34BetaE12) and thrombomodulin. No metastases were found in either of the patients, and one of them has survived for five years.ConclusionsThe diagnosis of low-grade urothelial carcinoma in prostate needle biopsies is difficult and may simulate benign prostate lesions including basal cell hyperplasia and urothelial metaplasia. It is crucial to recognize low-grade urothelial carcinoma in needle biopsies because only an early diagnosis and aggressive treatment can improve the prognosis for these patients.

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Transitional Cell Carcinoma involving the Prostate —An Unfavourable Prognostic Sign in the Management of Bladder Cancer?

Cited by 18 publications

References 4 publications

Clinical study of transitional cell carcinoma of the prostate associated with bladder transitional cell carcinoma

Clinical study of transitional cell carcinoma of the prostate associated with bladder transitional cell carcinoma

Are Biopsies From the Prostatic Urethra Useful in Patients With Superficial Bladder Carcinoma?

Low grade urothelial carcinoma mimicking basal cell hyperplasia and transitional metaplasia in needle prostate biopsy

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