Transitional cell carcinoma in high-grade high-stage ovarian carcinoma. An indicator of favorable response to chemotherapy

Robey, Susan S.; Silva, Elvio G.; Gershenson, David M.; McLemore, Donia; El‐Naggar, Adel K.; Ordóñez, Nelson G.

doi:10.1002/1097-0142(19890301)63:5<839::aid-cncr2820630508>3.0.co;2-u

Cited by 66 publications

(23 citation statements)

References 18 publications

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“…There is controversy about the significance of transitional cell pattern in ovarian carcinoma, and it has been suggested that this pattern is associated with a more favorable response to chemotherapy compared to usual HGSC; however, these findings have not been consistent, which is not surprising given the lack of reproducible diagnostic criteria, so that different case series undoubtedly have significant differences in case composition [81,[87][88][89][90][91]. It is possible that this pattern of growth is associated with improved resectability and response to chemotherapy, but the absence of reproducible diagnostic criteria or useful molecular markers makes definitive studies impossible at this time.…”

Section: Treatmentmentioning

confidence: 99%

Ovarian carcinoma pathology and genetics: recent advances

2009

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Section: Treatmentmentioning

confidence: 99%

Ovarian carcinoma pathology and genetics: recent advances

2009

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“…When these neoplasms are well sampled, they often contain foci of classic serous or endometrioid adenocarcinoma 83. There is some weak evidence that transitional carcinomas may be more chemoresponsive than other primary ovarian carcinomas 2 87. There has been little or no study of the underlying molecular events in ovarian transitional carcinoma.…”

Section: Transitional Carcinomamentioning

confidence: 99%

My approach to and thoughts on the typing of ovarian carcinomas

2007

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Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each with a different underlying pathogenesis and natural behaviour. Accurate classification of ovarian carcinomas is important since each type may be associated with a different behaviour, natural history and outcome. Precise classification is also critical to determine whether alternative therapeutic strategies are appropriate for different tumour types. Previous studies have shown significant interobserver variation in the typing of ovarian carcinomas. There are several areas where there are particular difficulties; these include the distinction between high-grade serous and endometrioid adenocarcinomas and the distinction between a true clear cell carcinoma and clear cell areas within other adenocarcinomas. This review details my approach to the typing of ovarian carcinomas. Morphological assessment, which remains the mainstay in diagnosis, can be supplemented by immunohistochemistry which, for example, is useful in the distinction between serous carcinomas (WT1 positive) and other carcinomas (generally WT1 negative). In recent years, there has been emerging new information regarding the major underlying molecular events in several types of ovarian carcinoma. This has resulted in the acceptance that there are two distinct types of ovarian serous carcinoma. These are termed low-grade and high-grade serous carcinoma, but represent two distinct tumour types rather than low-grade and high-grade variants of the same neoplasm. The integration of clinical, morphological and molecular data has resulted in a more precise classification of ovarian carcinomas and has resulted in the proposal for a broad dualistic pathway of ovarian epithelial carcinogenesis with, in general, low-grade type 1 tumours evolving from benign and borderline neoplasms through a well-defined adenoma-carcinoma sequence, and high-grade type 2 neoplasms arising from an, as yet, undefined precursor lesion.Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms. The major types of primary ovarian epithelial malignancy 1 are listed in the box. Each tumour type has a different underlying pathogenesis and natural behaviour. Although, currently, management of ovarian carcinoma is largely dependent on factors such as tumour grade and stage, and not usually on cell type, it is important to accurately type ovarian carcinomas to ascertain whether the various neoplasms have a different behaviour independent of stage and other clinicopathological parameters. Typing is also important since some tumours, such as mucinous and clear cell carcinoma, seem to exhibit a poor response to platinum-based chemotherapy. 2 In fact, tumour type may be a more reliable predictor of response to chemotherapy than tumour grade. 2This review details my thoughts on and approach to the typing of ovarian carcinomas and is meant as a guide to the practising surgical pathologist. Morphology remains the mainstay in diagnosis but immunohistochemistry may be of value as a...

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“…These are uncommon tumors; Silva et al estimated that they account for 1% of ovarian carcinomas (52). Transitional cell carcinomas may show a more favorable response to chemotherapy than other ovarian carcinomas, but this has not been a uniform finding (3,(52)(53)(54)(55)(56). With a recently recognized tumor subtype there will be problems with reproducibility in diagnosis.…”

Section: Transitional Cell Carcinomasmentioning

confidence: 99%

Subclassification of Ovarian Surface Epithelial Tumors Based on Correlation of Histologic and Molecular Pathologic Data

Gilks

2004

International Journal of Gynecological Pathology

110

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Surface epithelial tumors are a large and heterogeneous group of neoplasms that are subclassified based on cell type and malignant potential. The objective of this review is to examine the correlations between recent molecular pathology data and the traditional histopathologic classification of surface epithelial tumors. By doing so, 6 distinct subsets of ovarian epithelial neoplasia can be identified with potential treatment implications 1. high-grade serous, high-grade endometrioid, and undifferentiated carcinomas; 2. low-grade serous carcinomas and serous borderline tumors; 3. mucinous carcinomas and mucinous borderline tumors of intestinal type; 4. low-grade endometrioid carcinomas and endometrioid borderline tumors; 5. clear cell carcinomas; and 6. transitional cell carcinomas.

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Transitional cell carcinoma in high-grade high-stage ovarian carcinoma. An indicator of favorable response to chemotherapy

Cited by 66 publications

References 18 publications

Ovarian carcinoma pathology and genetics: recent advances

Ovarian carcinoma pathology and genetics: recent advances

My approach to and thoughts on the typing of ovarian carcinomas

Subclassification of Ovarian Surface Epithelial Tumors Based on Correlation of Histologic and Molecular Pathologic Data

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